中国中老年人代谢综合征及其组分对抑郁状态的双向关联  

Bidirectional association of metabolic syndrome and its components with depression in middle-aged and elderly Chinese people

作　　者：李语童 巢健茜[1] 周蔚 LI Yu-tong;CHAO Jian-qian;ZHOU Wei(School of Public Health,Southeast University,Nanjing,Jiangsu 210009,China)

机构地区：[1]东南大学公共卫生学院,江苏南京210009

出　　处：《现代预防医学》2024年第16期2881-2886,2910,共7页Modern Preventive Medicine

基　　金：国家社会科学基金重大项目(23&ZD188)。

摘　　要：目的探讨中国中老年人代谢综合征(Metabolic syndrome,MS)和抑郁状态的相互影响。方法本研究采用2011—2018年中国健康与退休纵向研究(CHARLS)数据中45岁及以上中老年人,基线采用2011年数据,阶段Ⅰ研究基线MS与新发抑郁状态的关联,阶段Ⅱ研究基线抑郁状态与新发MS的关联,阶段Ⅲ采用交叉滞后面板模型进一步研究两者双向关联,随访均采用包含血检与体检的2015年数据。结果两者存在双向关联,基线MS组分与随访抑郁状态(β=0.052,P<0.01)以及基线抑郁状态与随访MS组分(β=0.305,P<0.01)呈正相关,但MS组分在性别亚组上存在差异。结论中国中老年人群体MS及其组分与抑郁状态存在双向关联,应对其进行早期MS及抑郁状态的识别、监测及干预策略。Objective To explore the bidirectional association between metabolic syndrome(MS)and depression in middle-aged and elderly adults in China.Methods This study used participants aged 45 and above from publicly available longitudinal data from the China Health and Retirement Longitudinal Study(CHARLS)from 2011 to 2018.The baseline was based on 2011 data.Stage I studied the longitudinal association of baseline MS with follow-up depression,while Stage II studied the association of baseline depression with follow-up MS.Stage III further investigated the bidirectional association between MS and depression using a cross-lagged panel model,and the follow-up data for all three stages used 2015 data including blood routine examination and physical examinations.Results There was a bidirectional association between the two diseases.The baseline MS and its components showed a positive correlation with the follow-up depression(β=0.052,P<0.01),and vice versa(β=0.305,P<0.01),but there were differences in gender subgroups.Conclusion There is a bidirectional correlation between MS and its components and depression in the middle-aged and elderly population in China.We should identify,monitor,and intervene in early MS and depression.

关 键 词：代谢综合征 抑郁状态 双向关联 CHARLS 

分 类 号：R749.4[医药卫生—神经病学与精神病学]