宫腔微生物菌群诱导的免疫耐受对生殖结局的影响  

Impacts of immune tolerance induced by the uterine microbiota on reproductive outcomes

作　　者：俞锦雯 郑爱燕[1] 丁洁[1] 孟庆霞[1] Yu Jinwen;Zheng Aiyan;Ding Jie;Meng Qingxia(Reproduction and Genetics Center,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou Municipal Hospital,Suzhou215002,China)

机构地区：[1]南京医科大学附属苏州医院、苏州市立医院生殖与遗传中心,苏州215002

出　　处：《中华生殖与避孕杂志》2024年第8期858-861,共4页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划(2022YFC2702901);苏州市卫健委临床重点病种项目(LCZX202109)。

摘　　要：微生物组在人类生殖中的作用已成为"人类的第二基因组"。实际上, 对于生殖过程中微生物组的作用已有比较多的研究, 包括下生殖道和上生殖道, 甚至与配子发生时的相互作用。微生物组不仅在健康和微生态失调引起的病理状态中扮演着关键角色, 同时也可能在成功受精和健康妊娠中发挥了重要作用。目前, 关于微生物组和人类生殖轴之间关系的研究正引起广泛关注。本文综述了微生物菌群对生殖结局的影响, 及宫腔内的微生物菌群对免疫耐受的影响和可能的机制, 探讨菌群紊乱可能是通过免疫耐受来发挥作用的。这可能对微生态的调节和探索生殖疾病治疗新方法起到指导作用。The role of microbiota in human reproduction has become the“the second genome of humanity”.In fact,more and more researches have investigated the microbiota in reproduction,including the lower and upper reproductive tracts,and even the interactions with gametogenesis.The microbiota not only plays a crucial role in the pathological states caused by health and microecological disorders,but may also play an important role in successful fertilization and healthy pregnancy.Currently,researches on the relationship between microbiota and human reproductive axis are attracting widespread attention.This article reviews the impact of microbiota on reproductive outcomes,as well as the impact and possible mechanisms of microbiota in the uterine cavity on immune tolerance.It explores that dysbiosis of microbiota may play a role through immune tolerance.This may play a guiding role in regulating the microecology and exploring new methods for treating reproductive diseases.

关 键 词：宫腔 微生物群 免疫耐受 治疗 生殖结局 

分 类 号：R714.8[医药卫生—妇产科学]