Sirtuins家族蛋白在卵巢衰老过程中的作用  

Role of Sirtuins family proteins in ovarian aging

作　　者：王静[1] 程慧茹 章志国[1] 曹云霞[1] Wang Jing;Cheng Huiru;Zhang Zhiguo;Cao Yunxia(Department of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui Medical University,NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University),Anhui Province Key Laboratory of Reproductive Health and Genetics,Hefei 230032,China)

机构地区：[1]安徽医科大学第一附属医院妇产科、国家卫生健康委配子及生殖道异常研究重点实验室、生殖健康与遗传安徽省重点实验室,合肥230032

出　　处：《中华生殖与避孕杂志》2024年第7期759-763,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(82071724)。

摘　　要：衰老导致的卵巢功能衰退是不可逆的自然生理过程,表现为卵泡的逐渐耗竭和卵巢的卵母细胞质量下降。现有研究表明,Sirtuins家族通过多种途径参与卵巢衰老的发生发展,如调控烟酰胺腺嘌呤二核苷酸水平、氧化应激、染色体分离和基因组稳定性等。本文就目前Sirtuins家族蛋白在卵巢衰老中扮演的角色及其分子机制进行综述。The decline of ovarian function due to aging is an irreversible natural physiological process,manifested by the progressive depletion of follicles and the decrease of oocyte quality in the ovary.Existing studies have shown that the Sirtuins family is involved in the development of ovarian aging through various pathways,such as regulation of nicotinamide adenine dinucleotide levels,oxidative stress,chromosome segregation and genomic stability.In this paper,we review the current roles of Sirtuins family proteins in ovarian aging and their molecular mechanisms.

关 键 词：SIRTUINS 烟酰胺腺嘌呤二核苷酸 氧化应激 染色体分离 基因组稳定性 卵巢衰老 

分 类 号：R711.75[医药卫生—妇产科学]