环状RNA在非小细胞肺癌发生发展和诊疗作用中的进展  

Role of circular RNA in the development and diagnosis of non-small cell lung cancer

作　　者：杜薇 黄大伟 吴晓薇 汪洁 伊雪 Du Wei;Huang Dawei;Wu Xiaowei;Wang Jie;Yi Xue(School of Public Health,Fujian Medical University,Fuzhou 350122,China;Department of Basic Medicine,Xiamen Medical College,Xiamen 361023,China)

机构地区：[1]福建医科大学公共卫生学院,福州350122 [2]厦门医学院基础医学部,厦门361023

出　　处：《中国综合临床》2024年第4期307-311,共5页Clinical Medicine of China

基　　金：福建省教育厅教师教育科研项目(JAT190823);福建省“大学生创新创业训练计划”项目(202312631030);厦门市本土领军人才支持计划项目(厦委组〔2020〕89号)。

摘　　要：非小细胞肺癌是肺癌中最常见的一种类型,其病死率位居首位。非小细胞肺癌的发生发展与多基因调节有关。环状RNA是一种反向拼接而成的非编码RNA,在许多类型的生物细胞中均有广泛表达。环状RNA缺乏5′和3′末端,与线性RNA相比,环状RNA对核酸外切酶和核糖核酸酶具有更好的稳定性。随着高通量测序和生物信息学技术的发展,越来越多的环状RNA与肿瘤的相关性逐渐被认识。现就环状RNA在非小细胞肺癌发生发展和诊疗中的作用进行相关综述,旨在为进一步研究其机制提供新的思路。Non-small cell lung cancer(NSCLC)is the most common type of lung cancer and still has the highest mortality rate.The occurrence and development of non-small cell lung cancer are related to multi gene regulation.Circular RNA is a non coding RNA formed by reverse splicing,which is widely expressed in many types of biological cells.Circular RNA lacks 5'and 3'terminals,and compared to linear RNA,circular RNA has better stability towards exonuclease and ribonuclease.With the development of high-throughput sequencing and bioinformatics technology,the correlation between more and more circular RNAs and tumors is gradually being recognized.This article provides a review on the role of circular RNA in the occurrence,development,diagnosis,and treatment of non-small cell lung cancer,aiming to provide new ideas for further research on its mechanism.

关 键 词：非小细胞肺癌 环状RNA 生物学功能 

分 类 号：R734.2[医药卫生—肿瘤]