LRRC15在非肿瘤疾病发病机制中的研究进展  

Research progress in the role of LRRC15 in the pathogenesis of non-tumor diseases

作　　者：辛苗苗 关心 杨清锐 付敏 Xin Miaomiao;Guan Xin;Yang Qingrui;Fu Min(Department of Rheumatology and Immunology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院风湿免疫科,济南250021

出　　处：《中华微生物学和免疫学杂志》2024年第8期734-740,共7页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(82001744)。

摘　　要：富含亮氨酸重复蛋白15(leucine-rich repeat containing protein 15,LRRC15)基因编码具有15个富含亮氨酸重复序列(leucine-rich repeats,LRRs)的Ⅰ型跨膜蛋白,参与多种疾病的发生与发展。既往对LRRC15基因的研究多聚焦于肿瘤疾病中的促瘤作用,其在非肿瘤疾病中的免疫调控作用仍处于探索阶段,包括控制病毒感染、参与成骨细胞及软骨细胞功能的改变、促进促炎细胞因子释放及成骨分化,以及促进成纤维细胞样滑膜细胞的增殖、迁移和血管生成等。本文总结了LRRC15基因在非肿瘤疾病中的研究现状及角色,从而揭示该基因在免疫调控中的重要作用。Leucine-rich repeat containing protein 15(LRRC15)gene encodes a typeⅠtransmembrane protein with 15 leucine-rich repeats(LRRs),which is involved in the occurrence and development of various diseases.Previous studies on LRRC15 gene have mostly focused on its tumor-promoting effects,while the immunoregulatory roles of this gene in non-neoplastic diseases are in the exploratory stage,such as controlling viral infection,participating in changing the functions of osteoblasts and chondrocytes,and promoting the release of pro-inflammatory cytokines,osteogenic differentiation,as well as the proliferation,migration and angiogenesis of fibroblast-like synoviocytes.This paper summarizes the research status and possible roles of LRRC15 gene in non-tumor diseases,hoping to reveal the significant role of this gene in immune regulation.

关 键 词：LRRC15 感染 类风湿关节炎 骨性关节炎 成骨 

分 类 号：R363[医药卫生—病理学]