不同预后结直肠癌患者SGA评分及NLR表达及预后评估效能分析  

Analysis on the SGA Score and NLR Expression in Colorectal Cancer Patients with Different Prognosis and Efficacy of Prognosis Evaluation

作　　者：武亮 武雪亮[1] 王雅琳 刘辉[1] 乔建平 高树全[1] 喇彩凤 Wu Liang;Wu Xueliang;Wang Yalin;Liu Hui;Qiao Jianping;Gao Shuquan;La Caifeng(不详;The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei Province,China)

机构地区：[1]河北北方学院附属第一医院,湖北省张家口市075000 [2]解放军总医院京北医疗区,北京市100094

出　　处：《中国病案》2024年第8期109-112,共4页Chinese Medical Record

基　　金：国家癌症中心肿瘤科研专项(NCC2017A23);河北省科技厅重点研发计划(22377786D);河北省张家口市科技局指导性计划(2322031D)。

摘　　要：目的探究不同预后结直肠癌患者主观综合营养评估量表(Subjective Global Assessment,SGA)评分及中性粒细胞和淋巴细胞绝对值比值(neutrophil to lymphocyte ratio,NLR)表达,建立预后评估模型并检测该模型预后评估效能。方法研究对象选取某院2021年1月1日至2022年1月31日收治的进展期/晚期结直肠患者104例,根据患者治疗疗效评估分为预后良好组(50例)及预后不良组(54例),比较两组患者的SGA评分、营养学相关指标、NLR、MLR、PLR、WLR水平,随访患者生存期。分析预后独立影响因素,建立联合模型并评估联合模型预测价值。结果预后良好组TP、Hb水平、生存期显著高于预后不良组,主观整体评估(subjective global assessment,PG-SGA)评分、TF、NLR、MLR、PLR、WLR、ca199、cea、ca724水平显著低于预后不良组;患者生存期与TP、Hb呈正相关,与SGA评分、TF、NLR、MLR、PLR、WLR水平呈负相关;患者预后不良与TP、Hb呈负相关,与SGA评分、TF、NLR、MLR、PLR、WLR水平呈正相关;SGA、TP、TF、Hb、NLR、MLR、PLR、WLR为患者预后独立影响因素,P<0.05;联合模型预后评估效能优于肿瘤标志物。结论结直肠癌患者预后与其SGA评分及TP、Hb、TF、NLR、MLR、PLR、WLR水平密切相关,且基于SGA营养评分及NLR等指标建立结直肠癌预后预测模型对患者预后的评估具有较高的敏感度和特异度。Objectives To investigate the Subjective Global Assessment(SGA)score and neutrophil to lymphocyte ratio(NLR)expression of colorectal cancer patients with different prognosis,establish a prognosis assessment model and test its efficacy.Methods A total of 104 advanced/advanced colorectal patients admitted to our hospital from January 1st,2021 to January 31st,2022 were selected and divided into a good prognosis group(50cases)and a poor prognosis group(54 cases)according to the evaluation of therapeutic efficacy.The SGA score,nutrition-related indicators,NLR,MLR,PLR and WLR levels of the two groups were compared,and the survival period of the patients was followed up.The independent prognostic factors were analyzed,the combined model was established and the predictive value of the combined model was evaluated.Results The levels of TP,Hb and survival in the good prognosis group were significantly higher than those in the poor prognosis group,while the levels of SGA score,TF,NLR,MLR,PLR,WLR,ca199,cea and ca724 in the good prognosis group were significantly lower than those in the poor prognosis group.The survival of patients was positively correlated with TP and Hb,and negatively correlated with SGA score,TF,NLR,MLR,PLR and WLR levels.The poor prognosis of patients was negatively correlated with TP and Hb,and positively correlated with SGA score,TF,NLR,MLR,PLR and WLR.SGA,TP,TF,Hb,NLR,MLR,PLR and WLR were independent prognostic factors(P<0.05).The combined model was more effective than the tumor marker in evaluating prognosis.Conclusions The prognosis of patients with colorectal cancer was closely related to SGA score and the levels of TP,Hb,TF,NLR,MLR,PLR and WLR,and the prediction model of colorectal cancer prognosis based on SGA nutritional score and NLR had high sensitivity and specificity for the assessment of patient prognosis.

关 键 词：SGA MLR MLR PLR WLR 结直肠癌 预后1 

分 类 号：R735.34[医药卫生—肿瘤]