PRF对老年T2DM伴慢性牙周炎拔牙患者拔牙窝骨组织、软组织愈合的影响  

Effect of PRF on bone and soft tissue healing in extraction sockets of elderly patients with T2DM with chronic periodontal extraction

作　　者：翟新颖[1] 曲妍 陈茜 王立新[1] ZHAI Xinying;QU Yan;CHENG Qian;WANG Lixin(Department of stomatology,Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing 100144)

机构地区：[1]首都医科大学附属北京康复医院口腔科,北京100144

出　　处：《现代口腔医学杂志》2024年第4期258-263,共6页Journal of Modern Stomatology

基　　金：北京康复医院科研发展专项临床研究培育青年项目(2022-052)。

摘　　要：目的探讨富血小板纤维蛋白(PRF)对老年2型糖尿病(T2DM)伴慢性牙周炎拔牙患者拔牙窝骨组织、软组织愈合的影响。方法选取2020年2月~2023年4月医院收治的96例处于慢性牙周炎并因牙周炎需要拔牙的老年T2DM患者,按数字表法随机分为3组,每组32例,研究组拔牙窝放置PRF缝合、对照组正常搔刮拔牙窝不放置任何材料并缝合、空白组正常搔刮拔牙窝不放置任何材料。对比3组术前、术后12周拔牙窝骨密度,术后30 min、1周、4周、12周拔牙窝软组织愈合评分、龈沟液细胞因子[血小板衍生生长因子AB(PDGF-AB)、转化生长因子β(TGF-β1)、白介素-1β(IL-1β)、白介素-4(IL-4)、血管内皮生长因子(VEGF)]以及疼痛评分。结果研究组患者术后12周拔牙窝骨密度高于对照组和空白组,差异有统计学意义(P<0.05)。研究组患者术后1周、4周、12周拔牙窝软组织愈合评分低于对照组和空白组,同时对照组低于空白组,差异均有统计学意义(P<0.05)。术后30 min、12周研究组患者龈沟液PDGF-AB、TGF-β1浓度高于对照组和空白组;术后1周、4周研究组患者龈沟液PDGF-AB、TGF-β1、IL-1β、IL-4浓度高于对照组和空白组,VEGF浓度低于空白组和对照组,差异有统计学意义(P<0.05)。研究组患者术后1周、4周疼痛评分低于空白组和对照组,差异有统计学意义(P<0.05)。结论PRF可促进老年T2DM伴慢性牙周炎拔牙患者拔牙窝骨组织、软组织愈合,减轻炎症反应,降低疼痛程度,具有消炎、止痛、促进愈合作用。Objective To investigate the effect of platelet-rich fibrin(PRF)on bone and soft tissue healing in extraction sockets of elderly patients with type 2 diabetes mellitus(T2DM)with chronic periodontal extraction.Methods Ninety-six elderly patients with T2DM who were in the resting stage of chronic and required tooth extraction due to periodontitis and were admitted to our hospital from February 2020to April 2023 were randomly divided into three groups according to the number table method,32 cases in each group,with PRF suture placed in the extraction sockets of the study group,no material placed and sutured in the normal scratch extraction sockets of the control group,and no material placed in the normal scratch extraction sockets of the blank group.No material was placed in the blank group.The bone mineral density of the 3 groups before and 12 weeks after tooth extraction was compared,the soft tissue healing score,gingival sulcus fluid cytokines[platelet-derived growth factor AB(PDGF-AB),transforming growth factorβ(TGF-β1),interleukin-1β(IL-1β),interleukin-4(IL-4),vascular endothelial growth factor(VEGF)]and pain score were compared between the three groups at 30 min,1week,4 weeks and 12 weeks after surgery.Results The patients in the study group had higher bone density in the extraction sockets at 12 weeks postoperatively than in the control and blank groups,with statistically significant differences(P<0.05).The soft tissue healing scores of the extraction sockets of the patients in the study group were lower than those of the control and blank groups at 1,4 and 12 weeks after surgery,while the control group was lower than the blank group,and the differences were statistically significant(P<0.05).PDGFAB and TGF-β1 concentrations in the gingival sulcus fluid of patients in the study group were higher than those in the control and blank groups at 30 min and 12weeks after surgery;The concentrations of PDGF-AB,TGF-β1,IL-1β,and IL-4 in the gingival sulcus fluid of patients in the study group at 1 and 4 weeks pos

关 键 词：慢性牙周炎 富血小板纤维蛋白 2型糖尿病 拔牙窝骨组织 拔牙窝软组织 

分 类 号：R782.1[医药卫生—口腔医学]