银杏酮酯分散片联合硫酸氢氯吡格雷片治疗缺血性脑卒中的成本-效果  

Cost-effectiveness of Ginkgo Biloba Terpene Lactones Dispersive Tablets combined with Clopidogrel Bisulfate Tablets in the Treatment of Ischemic Stroke

作　　者：张士勤 李想 王欣 肖敦明 ZHANG Shi-Qin;LI Xiang;WANG Xin;XIAO Dun-Ming(Boya Zhihui Institute of Health,Beijing 100080,China;Jiangsu Shenlong Pharmaceutical Co.,LTD.,Yancheng 224200,China;Beijing Ainusen Pharmaceutical Technology Co.,LTD.,Beijing 100043,China;School of Public Health,Fudan University,Shanghai 200032,China)

机构地区：[1]博雅智汇大健康研究院,北京100080 [2]江苏神龙药业有限公司,江苏盐城224200 [3]北京艾诺森医药科技有限公司,北京100043 [4]复旦大学公共卫生学院,上海200032

出　　处：《中国药物经济学》2024年第7期12-15,共4页China Journal of Pharmaceutical Economics

摘　　要：目的评估银杏酮酯分散片联合硫酸氢氯吡格雷片相比于硫酸氢氯吡格雷片治疗缺血性脑卒中的成本-效果,为银杏酮酯分散片联合硫酸氢氯吡格雷片的临床用药提供决策证据。方法从医疗卫生体系角度出发,采用Microsoft Excel 2019软件构建决策树模型,模拟银杏酮酯分散片联合硫酸氢氯吡格雷片相比于硫酸氢氯吡格雷片治疗缺血性脑卒中的总成本和临床产出,并进行增量分析和单因素敏感性分析。其中成本数据来源于相关价格网站,疗效数据来源于文献。结果基础分析结果显示,银杏酮酯分散片联合硫酸氢氯吡格雷片相比于硫酸氢氯吡格雷片成本低(1656元vs.2795元),效果好(再次卒中发生率低,2.22%vs.10.00%),为绝对优势方案。单因素敏感性分析显示,对结果影响最大的前3位参数分别是:硫酸氢氯吡格雷片疗效、银杏酮酯分散片价格和银杏酮酯分散片联合硫酸氢氯吡格雷片疗效。结论银杏酮酯分散片联合硫酸氢氯吡格雷片相比于硫酸氢氯吡格雷片治疗缺血性脑卒中成本低,效果好,为绝对优势方案。Objective To evaluate the cost-effectiveness of Ginkgo Biloba Terpene Lactones dispersive tablets combined with Clopidogrel Bisulfate tablets compared with Clopidogrel Bisulfate tablets in the treatment of ischemic stroke,and to provide decision-making evidence for the clinical use of Ginkgo Biloba Terpene Lactones dispersive tablets combined with Clopidogrel Bisulfate tablets.Methods From the perspective of healthcare system,Microsoft Excel 2019 software was used to build a decision tree model to simulate the total cost and clinical output of Ginkgo Biloba Terpene Lactones Dispersive tablets combined with Clopidogrel Bisulfate tablets compared with Clopidogrel Bisulfate tablets in the treatment of ischemic stroke,and incremental analysis and single factor sensitivity analysis were conducted.The cost data came from the relevant price website,and the efficacy data came from the literature.Results The basic analysis results show that the combination of Ginkgo Biloba Terpene Lactones Dispersible tablets with Clopidogrel Bisulfate tablets is less costly(CNY 1,56 vs.CNY 2 795) and more effective(lower recurrent stroke incidence,2.22% vs.10.00%),making it an absolutely superior option.Univariate sensitivity analysis indicates that the three most influential parameters on the results are the efficacy of Clopidogrel Bisulfate tablets,the price of Ginkgo Biloba Terpene Lactones Dispersible tablets,and the combined efficacy of Ginkgo Biloba Terpene Lactones Dispersible tablets with Clopidogrel Bisulfate tablets.Conclusion Compared with Clopidogrel Bisulfate tablets,Ginkgo Biloba Terpene Lactones dispersive tablets combined with Clopidogrel Bisulfate tablets have lower cost and better effect in the treatment of ischemic stroke,representing an absolutely superior option that is worth promoting.

关 键 词：银杏酮酯分散片 硫酸氢氯吡格雷片 缺血性脑卒中 成本-效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R956[医药卫生—临床医学]