天然中草药及其提取物通过对肝星状细胞的抗氧化实现抗肝纤维化  

Natural Chinese Herbs and Their Extracts are Effective Against Liver Fibrosis Through Their Antioxidant Effects on HSC

作　　者：华慧 陈渝萍 HUA Hui;CHEN Yu-Ping(School of Pharmacy,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学药学院,湖南衡阳421001

出　　处：《中国药物经济学》2024年第7期108-112,共5页China Journal of Pharmaceutical Economics

基　　金：湖南省研究生科研创新项目(CX20190749)。

摘　　要：肝纤维化是肝脏对其自身慢性损伤产生的一种伤口愈合反应,肝纤维化的主要特点是肝星状细胞(HSC)的活化导致细胞外基质的过度异常沉积,该过程是一个可逆的过程。本文主要探讨黄酮类、萜苷类等天然化合物中的活性成分通过对HSC的抗氧化作用,抑制HSC的过度活化,以期能为天然化合物通过抗氧化作用抑制HSC活化进而治疗肝纤维化提供新思路。Liver fibrosis is a wound-healing response of the liver to its own chronic injury.The main feature of liver fibrosis is that the activation of hepatic stellate cells leads to excessive abnormal deposition of extracellular matrix,which is a reversible process.In this study,the active components of natural compounds such as flavonoids and terpene glycosides inhibited the overactivation of hepatic stellate cells through antioxidant effects on hepatic stellate cells,in order to provide new ideas for the treatment of hepatic fibrosis by natural compounds inhibiting the activation of hepatic stellate cells through antioxidant effects.

关 键 词：肝纤维化 肝星状细胞 活性氧 中草药 

分 类 号：R575.1[医药卫生—消化系统] R285.5[医药卫生—内科学]