Delivering Microrobots in the Musculoskeletal System  

作　　者：Mumin Cao Renwang Sheng Yimin Sun Ying Cao Hao Wang Ming Zhang Yunmeng Pu Yucheng Gao Yuanwei Zhang Panpan Lu Gaojun Teng Qianqian Wang Yunfeng Rui 

机构地区：[1]Department of Orthopaedics,Zhongda Hospital,School of Medicine,Southeast University,Nanjing,Jiangsu,People’s Republic of China [2]School of Medicine,Southeast University,Nanjing 210009,People’s Republic of China [3]Orthopaedic Trauma Institute(OTI),Southeast University,Nanjing 210009,People’s Republic of China [4]Jiangsu Key Laboratory for Design and Manufacture of Micro‑Nano Biomedical Instruments,School of Mechanical Engineering,Southeast University,Nanjing 210009,People’s Republic of China [5]Center of Interventional Radiology and Vascular Surgery,Department of Radiology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,People’s Republic of China

出　　处：《Nano-Micro Letters》2024年第11期585-617,共33页纳微快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81572187,No.81871812 and No.52205590);the Natural Science Foundation of Jiangsu Province(No.BK20220834);project supported by Ruihua Charity Foundation(YL20220525);the Start-up Research Fund of Southeast University(No.RF1028623098).

摘　　要：Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited efficacy.Patients often suffer chronic pain and might eventually have to undergo end-stage surgery.Therefore,future treatments should focus on early detection and intervention of regional lesions.Microrobots have been gradually used in organisms due to their advantages of intelligent,precise and minimally invasive targeted delivery.Through the combination of control and imaging systems,microrobots with good biosafety can be delivered to the desired area for treatment.In the musculoskeletal system,microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the body.Compared to traditional biomaterial and tissue engineering strategies,active motion improves the efficiency and penetration of local targeting of cells/drugs.This review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal system.We summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.

关 键 词：MICROROBOT Musculoskeletal system Targeted delivery Microrobotic systems Magnetic actuation 

分 类 号：TP242[自动化与计算机技术—检测技术与自动化装置]