HIPEC、PRAC联合腹腔镜手术在中晚期结直肠癌中的应用效果及对血清肿瘤标志物水平的影响  

Application effect of HIPEC,PRAC combined with laparoscopic surgery in advanced colorectal cancer and its influences on serum tumor markers levels

作　　者：尚云亮 颜军世 SHANG Yunliang;YAN Junshi(Baoji High-tech Hospital,Baoji 721000;Fufeng People's Hospital,Baoji 722200,China)

机构地区：[1]宝鸡高新医院,陕西宝鸡721000 [2]扶风县人民医院,陕西宝鸡722200

出　　处：《临床医学研究与实践》2024年第25期58-61,共4页Clinical Research and Practice

摘　　要：目的分析腹腔热灌注化疗(HIPEC)、术前区域动脉灌注化疗(PRAC)联合腹腔镜手术在中晚期结直肠癌中的应用效果及对血清肿瘤标志物水平的影响。方法选择2018年1月至2020年12月收治的60例中晚期结直肠癌患者,以编号的奇偶性将其分为观察组和对照组,各30例。两组均实施腹腔镜手术治疗,对照组实施PRAC,观察组在对照组基础上术后给予HIPEC。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的糖链抗原19-9(CA19-9)、糖链抗原125(CA125)、糖链抗原242(CA242)及癌胚抗原(CEA)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的CD4^(+)、CD8^(+)、CD4^(+)CD25^(+)、CD4^(+)/CD8^(+)及自然杀伤(NK)细胞比较,差异无统计学意义(P>0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论HIPEC、PRAC联合腹腔镜手术可提升中晚期结直肠癌患者的治疗效果,降低血清肿瘤标志物水平,改善预后,且安全性理想。Objective To analyze the application effect of hyperthermic intraperitoneal chemotherapy(HIPEC),preoperative regional intra-aterial chemotherapy(PRAC)combined with laparoscopic surgery in advanced colorectal cancer and its influences on serum tumor markers levels.Methods A total of 60 patients with advanced colorectal cancer admitted from January 2018 to December 2020 were selected and divided into observation group and control group according to the parity of numbers,with 30 cases in each group.Both groups were treated with laparoscopic surgery,the control group was treated with PRAC,and the observation group was treated with HIPEC on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125),carbohydrate antigen 242(CA242)and carcinoembryonic antigen(CEA)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,there were no significant differences in CD4^(+),CD8^(+),CD4^(+)CD25^(+),CD4^(+)/CD8^(+)and natural killer(NK)cells between the two groups(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion HIPEC,PRAC combined with laparoscopic surgery can improve the treatment effect of patients with advanced colorectal cancer,reduce the levels of serum tumor markers,improve the prognosis,and has ideal safety.

关 键 词：中晚期结直肠癌 术前区域动脉灌注化疗 腹腔镜手术 腹腔热灌注化疗 

分 类 号：R735.3[医药卫生—肿瘤]