瘦素受体基因rs1137101位点多态性与老年人群代谢相关脂肪性肝病发生风险的关系研究  

A study on relationship between polymorphism of leptin receptor gene rs1137101 locus and risk of metabolic-associated fatty liver disease in elderly population

作　　者：韦新焕[1] 马丽霞[1] 郭海清[1] 赵锦涵 曹振环[1] 杜晓菲[1] 仇丽霞[1] 张晶[1] Wei Xinhuan;Ma Lixia;Guo Haiqing;Zhao Jinhan;Cao Zhenhuan;Du Xiaofei;Qiu Lixia;Zhang Jing(Department Three of Liver Disease Center,Beijing You an Hospital,Capital Medical University,Beijing,100069,P.R.China)

机构地区：[1]首都医科大学附属北京佑安医院肝病中心三科,北京100069

出　　处：《老年医学与保健》2024年第4期920-924,共5页Geriatrics & Health Care

基　　金：北京市属医院科研培育计划项目(PX2024061);北京市卫生健康委员会高层次公共卫生技术人才建设项目(03-23)。

摘　　要：目的探讨瘦素受体(LEPR)基因rs1137101位点多态性与老年人代谢相关脂肪性肝病(MAFLD)发病风险的关系。方法2020年1月—2021年9月于北京市门头沟社区招募健康体检的1019例老年志愿者,其中MAFLD组569例、非MAFLD组450例。记录受试者的临床资料,基因芯片法检测LEPR-rs1137101多态性基因分型。Logistic回归分析评估基因多态性与MAFLD发生的关系。结果老年人群MAFLD患者携带rs1137101 G>A多态性较非MAFLD患者多(36.91%vs 24.00%,P<0.05)。携带LEPR-rs1137101 A等位基因与MAFLD的发生风险增加有关(OR=1.695,95%CI:1.1402.520,P<0.05)。结论老年人群LEPR-rs1137101 A基因可能与MAFLD的发生有关。Objective To investigate the relationship between polymorphism of leptin receptor gene rs1137101 locus and risk of metabolic-associated fatty liver disease(MAFLD)in the elderly.Methods From January 2020 to September 2021,1019 elderly volunteers were recruited from Mentougou Community in Beijing for physical examination,including 569 ones in the MAFLD group and 450 ones in the non-MAFLD group.Their clinical data were recorded,and the genotype of LEPR-rs1137101 polymorphism was detected by gene chip.Logistic regression analysis was used to evaluate the relationship between gene polymorphism and the occurrence of MAFLD.Results Among the elderly population,rs1137101 G>A polymorphism was more common in the MAFLD group than that in the non-MAFLD group(36.91%vs 24.00%,P<0.05).The LEPR-rs1137101 A allele was associated with an increased risk of MAFLD(OR=1.695,95%CI:1.140-2.520,P<0.05).Conclusion LEPR-rs1137101 A gene may be related to the occurrence of MAFLD in the elderly population.

关 键 词：老年 代谢相关脂肪性肝病 瘦素受体 基因多态性 

分 类 号：R575.5[医药卫生—消化系统]