抑郁情绪在睡眠质量影响轻度认知障碍老年人认知功能中的中介作用  

The mediating effect of depression in the associations between sleep quality and cognitive functions in impairment

作　　者：邬锡波 王佳宇 韩红霞 沙开辉 杨琳露 卢仙飞 薛将[2,4] 陈树林 Wu Xibo;Wang Jiayu;Han Hongxia;Sha Kaihui;Yang Linlu;Lu Xianfei;Xue Jiang;Chen Shulin(Third Hospital of Haishu District,Ningbo 315191,China;Department of Psychology and Behavioral Science,Hangzhou 310028,China;Jiaring School,Jiaring 314001,China;School of Humanities and Management,Guangdong Medical University,Dongguan 523808,China)

机构地区：[1]宁波市海曙区第三医院,宁波315191 [2]浙江大学心理与行为科学系,杭州310028 [3]嘉兴学院,嘉兴314001 [4]广东医科大学人文与管理学院,东莞523808

出　　处：《中华老年医学杂志》2024年第8期1054-1058,共5页Chinese Journal of Geriatrics

基　　金：教育部人文社会科学一般项目(22YJCZH209);国家博士后科学基金项目(2020TQ0265);宁波市医学科技计划项目(2020Y31)。

摘　　要：目的探讨轻度认知障碍(MCI)老年人的睡眠质量对其认知功能的影响,并分析抑郁情绪在其中起到的中介作用。方法横断面研究,于2021年4-6月对宁波市海曙区310名MCI老年人进行现场问卷调查,其中有效问卷299份。调查内容包括基本人口学信息、蒙特利尔认知评估量表、病人健康问卷抑郁量表以及匹兹堡睡眠质量指数量表。结果MCI患者的认知能力与受教育程度呈正相关(F=3.89,P<0.05);睡眠质量与抑郁情绪呈正相关(r=0.40,P<0.01),与认知功能呈负相关(r=-0.22,P<0.01);抑郁情绪与认知功能呈负相关(r=-0.20,P<0.01)。中介分析结果显示,抑郁情绪在睡眠质量对认知功能的影响中起部分中介作用,中介效应大小为-0.02(95%CI:-0.03~-0.01)。结论睡眠质量会显著影响MCI老年人的认知功能,抑郁情绪在其中起到部分中介作用。Objective To examine the impact of sleep quality on cognitive function in older adults with mild cognitive impairment(MCI)and explore the potential mediating role of depression.Methods Using a cross-sectional design,we conducted an on-site questionnaire survey among 310 elderly individuals with MCI in Haishu District,Ningbo City from April to June 2021.Out of the 310 questionnaires collected,299 were deemed valid.The survey encompassed gathering basic demographic information of the participants,as well as administering the Montreal Cognitive Assessment Scale.Patient Health Questionnaire Depression Scale,and Pittsburgh Sleep Quality Index Scale.Results The cognitive functions of patients with MCI were found to be positively related to their education level(F=3.89,P<0.05).The correlation analysis indicated that sleep quality was positively correlated with depression(r=0.40,P<0.01)and negatively correlated with cognitive function(r=-0.22,P<O.01).Furthermore,a significant negative correlation was observed between depression and cognitive function(r=-0.20,P<0.01).The mediation analysis revealed that depression played a role in mediating the influence of sleep quality on cognitive function,with a mediation effect of-0.02(95%CI:-0.03-0.01).Conclusions The cognitive function of elderly individuals with MCI can be significantly affected by sleep quality,with depression playing a mediating role.

关 键 词：轻度认知障碍 睡眠质量 抑郁情绪 中介效应 

分 类 号：R749.1[医药卫生—神经病学与精神病学]