Five-year analysis of isolated pathogens and antibiotic resistance of ocular infections from two large tertiary comprehensive hospitals in east China  

作　　者：Pan-Pan Li Li Li Jun-Fang Zhang Bai Qin Li-Hua Kang Min Ji Huai-Jin Guan 

机构地区：[1]Suzhou Medical College of Soochow University,Suzhou 215123,Jiangsu Province,China [2]Department of Ophthalmology,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China [3]Department of Clinical Laboratory,Nantong City No.1 People’s Hospital and Second Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第9期1707-1716,共10页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(No.82101101).

摘　　要：AIM:To analyze the spectrum of isolated pathogens and antibiotic resistance for ocular infections within 5y at two tertiary hospitals in east China.METHODS:Ocular specimen data were collected from January 2019 to October 2023.The pathogen spectrum and positive culture rate for different infection location,such as keratitis,endophthalmitis,and periocular infections,along with antibiotic resistance were analyzed.RESULTS:We included 2727 specimens,including 827(30.33%)positive cultures.A total of 871 strains were isolated,530(60.85%)bacterial and 341(39.15%)fungal strains were isolated.Gram-positive cocci(GPC)were the most common ocular pathogens.The most common bacterial isolates were Staphylococcus epidermidis(25.03%),Staphylococcus aureus(7.46%),Streptococcus pneumoniae(4.59%),Corynebacterium macginleyi(3.44%),and Pseudomonas aeruginosa(3.33%).The most common fungal genera were Fusarium spp.(12.74%),Aspergillus spp.(6.54%),and Scedosporium spp.(5.74%).Staphylococcus epidermidis strains showed more than 50%resistance to fluoroquinolones.Streptococcus pneumoniae and Corynebacterium macginleyi showed more than 90%resistance to erythromycin.The percentage of bacteria showing multidrug resistance(MDR)significantly decreased(χ^(2)=17.44,P=0.002).CONCLUSION:GPC are the most common ocular pathogens.Corynebacterium macginleyi,as the fourth common bacterium,may currently be the local microbiological feature of east China.Fusarium spp.is the most common fungus.More than 50%of the GPC are resistant to fluoroquinolones,penicillins,and macrolides.However,the proportion of MDR strains has been reduced over time.

关 键 词：ocular infections BACTERIA FUNGUS antibiotic resistance multidrug resistance 

分 类 号：R77[医药卫生—眼科] R446.5[医药卫生—临床医学]