1565 nm非剥脱点阵激光联合A型肉毒毒素注射治疗眶周皱纹疗效分析  

Efficacy of 1565 nm Non-ablative Fractional Laser Combined with Type A Botulinum Toxin Injection in Periorbital Wrinkles

作　　者：王莉文 方静 王静 甘智慧 王娟 WANG Liwen;FANG Jing;WANG Jing;GAN Zhihui;WANG Juan(Graduate School of Bengbu Medial College,Bengbu 233030,Anhui,China;Department of Dermatology,the First Affiliated Hospital of USTC,Division of Life Science and Medicine,University of Science and Technology of China,Hefei 230001,Anhui,China)

机构地区：[1]蚌埠医科大学研究生院,安徽蚌埠233030 [2]中国科学技术大学附属第一医院(安徽省立医院)皮肤科,安徽合肥230001

出　　处：《中国美容医学》2024年第9期87-91,共5页Chinese Journal of Aesthetic Medicine

基　　金：中央高校基本科研业务专项基金(编号:WK9110000114)。

摘　　要：目的:探究1565 nm非剥脱点阵激光联合A型肉毒毒素注射治疗眶周皱纹的疗效。方法:纳入2022年10月-2023年8月笔者科室诊治的108例眶周皱纹就医者为研究对象,按照随机数表法分为肉毒毒素组(A型肉毒毒素注射组)、激光组(1565 nm非剥脱点阵激光治疗组)和联合治疗组(1565 nm非剥脱点阵激光联合A型肉毒毒素注射组),每组就医者均为36例。在治疗后第4周、12周、24周时随访三组就医者,采用VISIA皮肤分析仪皱纹评分、Fitzpatrick面部皱纹分级评分、整体美学改善量表(Global aesthetic improvement scale,GAIS)评分,评价三组就医者治疗效果并记录不良反应。结果:在治疗后第4、12、24周随访,三组就医者VISIA皱纹评分和Fitzpatrick皱纹评分较治疗前均有不同程度的下降;在治疗后第4周和12周时,联合组及肉毒毒素组VISIA皱纹评分和Fitzpatrick皱纹评分均低于激光组(P<0.05),联合组与肉毒毒素组两组间差异无统计学意义(P>0.05);在治疗后第24周时,肉毒毒素组就医者眶周VISIA皱纹评分和Fitzpatrick皱纹评分上升,均为联合组<激光组<肉毒毒素组(P<0.05)。联合组在治疗后4周、12周、24周时GAIS评分总有效率均高于激光组和肉毒毒素组(P<0.05)。结论:1565 nm非剥脱点阵激光联合A型肉毒毒素治疗改善眶周疗效显著持久,安全性好,美学效果更佳。Objective To investigate the efficacy of 1565 nm non-ablative fractional laser combined with type A botulinum toxin injection in the treatment of periorbital wrinkles.Methods A total of 108 patients with periorbital wrinkles treated in the author's department from October 2022 to August 2023 were enrolled in this study.They were randomly divided into three groups:the botulinum toxin group(type A botulinum toxin injection group),the laser group(1565 nm non-ablative fractional laser treatment group),and the combination therapy group(1565 nm non-ablative fractional laser combined with type A botulinum toxin injection group),with 36 patients in each group.The patients were followed up at 4 weeks,12 weeks,and 24 weeks after treatment.Wrinkle scores were evaluated using the VISIA skin analysis system,Fitzpatrick facial wrinkle grading scale,and the Global Aesthetic Improvement Scale(GAIS)to assess the treatment effects of the three groups and record adverse reactions.Results At the 4th,12th,and 24th weeks after the initial treatment,the VISIA scores and Fitzpatrick scores of the three groups showed varying degrees of improvement compared to before treatment.At the 4th and 12th weeks after the initial treatment,the VISIA scores and Fitzpatrick scores in the combination therapy group and the botulinum toxin group were lower than those in the laser group(P<0.05),with no significant statistical difference between the two groups(P>0.05).However,at the 24th week after the initial treatment,the periorbital wrinkle scores of the botulinum toxin group increased,with the VISIA scores and Fitzpatrick scores in the order of combination therapy group<laser group<botulinum toxin group(P<0.05).The combination therapy group had a significantly higher total effective rate of GAIS scores than the laser group and the botulinum toxin group at 4 weeks,12 weeks,and 24 weeks after the initial treatment(P<0.05).Conclusion 1565 nm non-ablative fractional laser combined with Type A botulinum toxin treatment significantly improves periorbital th

关 键 词：非剥脱点阵激光 A型肉毒毒素 眶周皱纹 VISIA面部检测 

分 类 号：R730.57[医药卫生—肿瘤]