MarR family proteins sense sulfane sulfur in bacteria  

作　　者：Guanhua Xuan Luying Xun Yongzhen Xia 

机构地区：[1]State Key Laboratory of Microbial Technology,Shandong University,Qingdao,China [2]State Key Laboratory of Marine Food Processing&Safety Control,Ocean University of China,Qingdao,China [3]School of Molecular Biosciences,Washington State University,Pullman,Washington,USA

出　　处：《mLife》2024年第2期231-239,共9页微生物（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.92351302,91951202,and 32201982).

摘　　要：Members of the multiple antibiotic resistance regulator(MarR)protein family are ubiquitous in bacteria and play critical roles in regulating cellular metabolism and antibiotic resistance.MarR family proteins function as repressors,and their interactions with modulators induce the expression of controlled genes.The previously characterized modulators are insufficient to explain the activities of certain MarR family proteins.However,recently,several MarR family proteins have been reported to sense sulfane sulfur,including zero-valent sulfur,persulfide(R-SSH),and polysulfide(R-SnH,n≥2).Sulfane sulfur is a common cellular component in bacteria whose levels vary during bacterial growth.The changing levels of sulfane sulfur affect the expression of many MarR-controlled genes.Sulfane sulfur reacts with the cysteine thiols of MarR family proteins,causing the formation of protein thiol persulfide,disulfide bonds,and other modifications.Several MarR family proteins that respond to reactive oxygen species(ROS)also sense sulfane sulfur,as both sulfane sulfur and ROS induce the formation of disulfide bonds.This review focused on MarR family proteins that sense sulfane sulfur.However,the sensing mechanisms reviewed here may also apply to other proteins that detect sulfane sulfur,which is emerging as a modulator of gene regulation.

关 键 词：cysteine thiols disulfide bond MarR protein family ROS sulfane sulfur 

分 类 号：Q93[生物学—微生物学]