兴奋性氨基酸转运体家族及其在眼科疾病中的研究进展  

The Excitatory Amino Acid Transporter Family and Research Progress in Ophthalmic Diseases

作　　者：胡晨阳(综述) 冯砚琳 许跃 黄晶晶(审校)[1] HU Chenyang;FENG Yanlin;XU Yue;HUANG Jingjing(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology Visual Science,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州510060

出　　处：《眼科学报》2024年第6期291-298,共8页Eye Science

基　　金：国家自然科学基金面上项目(82271081)。

摘　　要：谷氨酸是哺乳动物中枢神经系统中的主要兴奋性神经递质,谷氨酸酶系统的持续激活会导致神经元的兴奋性毒性,进而引起神经元损伤和细胞死亡。兴奋性氨基酸转运体家族成员是一种多次跨膜蛋白,位于突触前膜、突触囊泡和神经胶质细胞膜上,也是一种高亲和力的钠钾依赖性载体,能够不断清除细胞外残留的谷氨酸,维持正常的突触内外谷氨酸水平和细胞内氧化还原稳态,对于保护细胞免受兴奋性毒性以及氧化应激损伤至关重要,兴奋性氨基酸转运体家族成员表水平达的失调与多种中枢神经系统疾病神经退行性变的发生和发展密切相关。在视网膜组织中,兴奋性氨基酸转运体家族成员广泛表达。目前大量研究表明,兴奋性氨基酸转运体家族成员广泛参与了青光眼、视网膜缺血再灌注损伤、年龄相关性黄斑变性等眼部疾病的发病,但具体机制有待进一步阐明。为此,文章综述了兴奋性氨基酸转运体家族成员的生理功能及其在相关眼科疾病发生和发展中作用的研究进展,为进一步阐明相关眼病发病的分子机制及新的防治靶点的发现提供新的视角。SGlutamate is the primary excitatory neurotransmitter in the mammalian central nervous system.Persistent activation of the glutamatergic system can lead to excitotoxicity,resulting in neuronal damage and cell death.Members of the excitatory amino acid transporter(EAAT)family are multi-transmembrane proteins located on the presynaptic membrane,synaptic vesicles,and glial cell membranes.They function as high-affinity,sodium-potassium-dependent transporters,continuously clearing extracellular residual glutamate to maintain normal intra-and extracellular glutamate levels and intracellular redox homeostasis.This process is crucial for protecting cells from excitotoxicity and oxidative stress-induced damage.Dysregulation of EAATs is closely associated with the onset and progression of neurodegenerative diseases in the central nervous system.EAAT family members are widely expressed in retina.Numerous studies have demonstrated that these transporters are extensively involved in the pathogenesis of ocular diseases,including glaucoma,retinal ischemia-reperfusion injury,and age-related macular degeneration,although the specific mechanisms remain to be elucidated.Therefore,this article reviews the physiological functions of EAAT family members and their role in the development and progression of related ophthalmic diseases,providing new perspectives for further understanding the molecular mechanisms underlying these conditions and identifying novel therapeutic targets.

关 键 词：兴奋性氨基酸转运体 谷氨酸 眼科疾病 

分 类 号：R77[医药卫生—眼科] Q421[医药卫生—临床医学]