血清核苷酸结合寡聚化结构域样受体3、小窝蛋白-1、胱抑素C水平联合检测对高血压脑出血患者疾病转归的预测价值  

Predictive value of combined detection of serum levels of NLRP3,caveolin-1 and Cys C on disease outcome in patients with hypertensive intracerebral hemorrhage

作　　者：骆清华 方伟 朱小兰 Luo Qinghua;Fang Wei;Zhu Xiaolan(Department of Neurosurgery,Yiwu Central Hospital,Yiwu,Zhejiang 322000,China)

机构地区：[1]义乌市中心医院神经外科,浙江义乌322000

出　　处：《中国微侵袭神经外科杂志》2023年第12期114-118,共5页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的观察高血压脑出血(hypertensive intracerebral hemorrhage,HICH)患者血清核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)、小窝蛋白-1(caveolin-1)、胱抑素C(cystatin C,Cys C)水平,并探究其对疾病转归的预测价值。方法回顾性选取接受微创穿刺血肿引流术治疗的184例HICH患者作为研究组,另选取同期健康志愿者62例作为对照组。比较两组血清NLRP3、Caveolin-1、Cys C水平。依据术后90 d疾病转归情况将研究组患者分为转归不良亚组89例,转归良好亚组95例;比较其术前、术后7d血清NLRP3、Caveolin-1、Cys C水平。多因素Logistic回归分析疾病转归的影响因素。评价术后7d血清NLRP3、Caveolin-1、Cys C水平对术后90d疾病转归的预测价值。结果研究组血清NLRP3、Caveolin-1、Cys C水平高于对照组(P<0.05)。转归不良亚组术后7d血清NLRP3、Caveolin-1、Cys C水平高于转归良好亚组(P<0.05)。血肿体积、血肿破入脑室及血清NLRP3、Caveolin-1、Cys C水平为转归不良的危险因素(P<0.05)。术后7d血清NLRP3、Caveolin-1、Cys C联合预测术后90d疾病转归不良的AUC大于单项指标预测(P<0.05)。结论HICH患者血清NLRP3、Caveolin-1、Cys C水平升高,其对疾病转归具有一定预测价值,联合检测其水平可提高预测效能。Objective To observe the serum levels of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3),Caveolin-1(caveolin-1)and cystatin C(Cys C)in patients with hypertensive intracerebral hemorrhage(HICH),and to explore their predictive value for disease outcome.Methods A total of 184 patients with HICH who received minimally invasive puncture hematoma drainage were selected as the study group,and 62 healthy volunteers from the same period were selected as the control group.The serum levels of NLRP3,caveolin-1 and Cys C were compared between the two groups.The patients in the study group were divided into a poor outcome subgroup of 89 cases and a good outcome subgroup of 95 cases according to the disease outcome at 90 days after operation,their preoperative and 7-d postoperative serum levels of NLRP3,caveolin-1 and Cys C were compared.Multivariate logistic regression was used to analyze the influencing factors of disease outcome.The predictive value of serum levels of NLRP3,caveolin-1,and Cys C at 7d after operation was evaluated for disease outcomes at 90d after operation.Results The serum levels of NLRP3,caveolin-1 and Cys C in the study group were higher than those in the control group(P<0.05).The serum levels of NLRP3,caveolin-1 and Cys C in the poor outcome subgroup were higher than those in the good outcome subgroup at 7d after operation(P<0.05).Hematoma volume,hematoma breaking into ventricle and serum levels of NLRP3,caveolin-1,Cys C were risk factors for poor outcome(P<0.05).The AUC of combined prediction of NLRP3,caveolin-1 and Cys C at 7d after operation was greater than that of single index prediction at 90d after operation(P<0.05).Conclusions The serum levels of NLRP3,caveolin-1 and Cys C in patients with HICH are increased,which has a certain predictive value for the disease outcome,and combined detection of their levels can improve the predictive efficiency.

关 键 词：脑出血 高血压 核苷酸结合寡聚化结构域样受体3 小窝蛋白-1 胱抑素C 

分 类 号：R743[医药卫生—神经病学与精神病学]