脂蛋白相关磷脂酶A2、可溶性凝集素样氧化型低密度脂蛋白受体-1以及氧化修饰低密度脂蛋白水平与高血压脑出血患者预后的相关性研究  

Correlation between Lp-PLA2,sLOX-1 and ox-LDL levels and prognosis of hypertensive intracerebral hemorrhage

作　　者：陈加梅 段勇刚[2] Chen Jiamei;Duan Yonggang(Clinical Laboratory,Luohe Central Hospital,Luohe,Henan 462000,China;Department of Neurosurgery,Luohe Central Hospital,Luohe,Henan 462000,China)

机构地区：[1]漯河市中心医院检验科,河南漯河462000 [2]漯河市中心医院神经外科,河南漯河462000

出　　处：《中国微侵袭神经外科杂志》2023年第12期119-122,共4页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的分析脂蛋白相关磷脂酶A2(Lipoprotein-associated phospholipaseA2,Lp-PLA2)、可溶性凝集素样氧化型低密度脂蛋白受体-1(soluble lectin-like oxidized low-density lipoprotein receptor-1,sLOX-1)、氧化修饰低密度脂蛋白(oxidized low-density lipoprotein,ox-LDL)水平与高血压脑出血(hypertensive intracerebral hemorrhage,HICH)患者预后的相关性。方法回顾性分析66例HICH病例资料,患者术后均持续随访1个月,使用格拉斯哥预后评分(Glasgow outcome sacle,GOS)评估患者预后,GOS 1~3分为预后不良(n=32),GOS 4~5分为预后良好(n=34)。比较两组基线资料、Lp-PLA2、sLOX-1、ox-LDL水平和美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分。采用Pearson相关性分析法分析HICH患者Lp-PLA2、sLOX-1、ox-LDL水平与NIHSS评分的相关性。使用受试者工作特征曲线(Receiver operator characteristic curv,ROC)分析Lp-PLA2、sLOX-1、ox-LDL水平评估HICH患者预后的价值。结果两组HICH患者性别、年龄、发病至入院时间、高血压病程,差异无统计学意义(P>0.05),但预后不良组HICH患者出血量、Lp-PLA2、sLOX-1、ox-LDL水平与NIHSS评分均高于预后良好组(均P<0.05)。Pearson相关性分析结果显示:HICH患者Lp-PLA2、sLOX-1、ox-LDL水平与NIHSS评分均呈正相关(P<0.05)。ROC分析结果显示:Lp-PLA2、sLOX-1、ox-LDL水平在评估HICH患者预后的最佳临界值分别为157.75μg/L、362.50ng/L、54.15μg/dL,曲线下面积分别为0.793、0.900、0.793(P<0.05),敏感度分别为75.00%、87.50%、78.13%,特异度分别为82.35%、82.35%、76.47%。结论预后不良组HICH患者Lp-PLA2、sLOX-1、ox-LDL水平呈高表达,Lp-PLA2、sLOX-1、ox-LDL水平越高,神经损伤越严重,且Lp-PLA2、sLOX-1、ox-LDL水平在评估HICH患者预后中具有一定价值。Objective To analyze the correlation between lipoprotein-associated phospholipase A2(Lp-PLA2),soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1),oxidized low-density lipoprotein(ox-LDL)levels and prognosis of hypertensive intracerebral hemorrhage(HICH)patients.Methods The clinical data of 66 patients with HICH were retrospectively analyzed.All patients were followed up for 1 month after surgery.The prognosis of patients was assessed using the Glasgow Outcome Scale(GOS).Scores 1 to 3 were classified as poor prognosis(n=32)and 4 to 5 as good prognosis(n=34).Baseline data,Lp-PLA2,sLOX-1,ox-LDL levels and National Institute of Health stroke scale(NIHSS)scores in the two groups were compared.The correlation between Lp-PLA2,sLOX-1,ox-LDL levels and NIHSS score in HICH patients was analyzed by Pearson correlation analysis.Receiver operator characteristic(ROC)curve analysis of Lp-PLA2,sLOX-1 and ox-LDL levels was used to evaluate the prognosis of patients with HICH.Results There were no differences in the gender,age,time from onset to admission and course of hypertension between the two groups(P>0.05),but the blood loss of HICH patients in the poor prognosis group was higher(P<0.05).The levels of Lp-PLA2,sLOX-1,ox-LDL and NIHSS in HICH patients with poor prognosis were higher than those in good prognosis group(P<0.05).Pearson correlation analysis showed that the levels of Lp-PLA2,sLOX-1 and ox-LDL were positively correlated with NIHSS score in HICH patients(P<0.05).ROC analysis results showed that the optimal critical values of Lp-PLA2,sLOX-1 and ox-LDL levels for prognosis with HICH were 157.75μg/L,362.50 ng/L and 54.15μg/dL,respectively.The areas under the curve were 0.793,0.900 and 0.793,respectively(P<0.05).The sensitivity was 75.00%,87.50%,78.13%,and the specificity was 82.35%,82.35%,76.47%,respectively.Conclusion The levels of Lp-PLA2,sLOX-1 and ox-LDL in patients with HICH in the poor prognosis group show high expression,and the higher the levels of Lp-PLA2,sLOX-1 and ox-LDL in patients with

关 键 词：脑出血 高血压 脂蛋白相关磷脂酶A2 可溶性凝集素样氧化型低密度脂蛋白受体-1 氧化修饰低密度脂蛋白 神经功能 

分 类 号：R743[医药卫生—神经病学与精神病学]