基质金属蛋白酶在癌症中的作用  

Role of matrix metalloproteinases in cancer

作　　者：张永红[1] 赵奇[1] 陆昌瑞 陈婷[1] ZHANG Yonghong;ZHAO Qi;LU Changrui;CHEN Ting(College of Biological Science and Medical Engineering,Donghua University,Shanghai 201619,China)

机构地区：[1]东华大学生物与医学工程学院,上海201619

出　　处：《生命的化学》2024年第7期1151-1160,共10页Chemistry of Life

基　　金：国家科技重大专项(民口)项目(2014ZX09J14103-09C-003);上海市科学技术委员会自然科学基金项目(19ZR1471100);上海市科学技术委员会国际合作计划项目(19410711000)。

摘　　要：癌症也称恶性肿瘤,源于细胞的异常增殖,具有侵袭与转移的特点,对人类的生命安全造成了严重威胁。对肿瘤的早期切除和术后化疗与放疗等手段尽管有一定治疗效果,但同时存在一定毒性和不良反应。因此,探索新的肿瘤治疗方案尤为迫切。本文综述了基质金属蛋白酶家族在癌症中的作用,及其作为抗肿瘤药物靶点的广阔应用前景。研究表明,基质金属蛋白酶(matrix metalloproteinases,MMPs)家族在各种肿瘤微环境中表达量升高,且因其对细胞外基质的切割作用,成为促进肿瘤细胞的侵袭和转移的重要因素。目前,MMPs已成为抗肿瘤药物的热门靶点和肿瘤的生物标志物之一,具有广泛的研究价值。Cancer,also known as malignant tumor,originates from abnormal cell proliferation,characterized by invasiveness and metastasis,posing a severe threat to human life safety.The early surgical removal of tumors and postoperative treatments such as chemotherapy and radiotherapy have certain therapeutic effects on cancer,but they also come with certain toxicity and side effects.Therefore,the exploration of new cancer treatment approaches is becoming increasingly urgent.This work reviews the role of the matrix metalloproteinases(MMPs)family in cancer,as well as the broad prospects of its use as a target for anti-tumor drugs.Research has shown that the MMPs family has elevated expression levels in various tumor microenvironments,and its ability to cleave the extracellular matrix is an important factor promoting the invasion and metastasis of cancer cells.MMPs have become a popular drug target for anti-cancer therapy and a biomarker for cancer,with a wide range of research value.

关 键 词：癌症 基质金属蛋白酶家族 抗肿瘤药物 抑制剂 

分 类 号：R73-3[医药卫生—肿瘤]