调节性细胞死亡在胃癌发生发展中的作用  

Role of regulated cell death in the development of gastric cancer

作　　者：于洋[1] 徐芸[1] 曹婧媛 韩俊岭 周成林 YU Yang;XU Yun;CAO Jingyuan;HAN Junling;ZHOU Chenglin(Department of Laboratory Medicine,the Affiliated Taizhou People's Hospital of Nanjing Medical University,Taizhou 225300,Jiangsu,China)

机构地区：[1]南京医科大学附属泰州人民医院检验科,泰州225300

出　　处：《中国临床医学》2024年第4期652-658,共7页Chinese Journal of Clinical Medicine

基　　金：泰州市人民医院科研基金(ZL202041)。

摘　　要：胃癌是全球最常见的恶性肿瘤之一,其发病率和死亡率在我国恶性肿瘤中均位居第3。调节性细胞死亡(regulated cell death,RCD)是由信号转导模块激活而引起的一种细胞死亡形式,与胃癌的进展和治疗密切相关。RCD包括多种形式,如凋亡、焦亡、铁死亡、铜死亡、自噬等。这些形式不仅在清除受损细胞中发挥作用,还在抑制胃癌扩散中扮演着重要角色。本文综述了不同RCD形式在胃癌发生发展中的作用,旨在为胃癌的新型诊疗方法提供参考。Gastric cancer is one of the most common malignant tumors worldwide, with its incidence and mortality rates ranking third among malignant tumors in China. Regulated cell death(RCD) is a type of cell death activated by signal transduction modules and closely connected to the progression and treatment of gastric cancer. Different types of RCD, comprising apoptosis,pyroptosis, ferroptosis, cuproptosis, and autophagy, not only aid in eliminating damaged cells, but also serve a crucial role in suppressing gastric cancer spread. This paper reviews different forms of RCD and their roles in the progression of gastric cancer, so as to provide reference for new diagnosis and treatment strategies of gastric cancer.

关 键 词：胃癌 调节性细胞死亡 凋亡 焦亡 铁死亡 铜死亡 自噬 

分 类 号：R735.2[医药卫生—肿瘤]