妊娠相关因素与子宫内膜癌风险关系探讨  

Exploring the relationship between pregnancy-related factors and the risk of endometrial cancer

作　　者：张瑞[1] 周建政[1] Zhang Rui;Zhou Jianzheng(Department of Obstetrics and Gynecology,the Second Hospital of Shanxi Medical University,Taiyuan Shanxi 030001,P.R.China)

机构地区：[1]山西医科大学第二医院妇产科,山西太原0300011

出　　处：《中国计划生育和妇产科》2024年第8期90-94,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的探讨妊娠相关因素与子宫内膜癌风险的关系,并从该角度筛查高危人群。方法收集2022年1月至2023年10月在山西医科大学第二医院经病理诊断确诊并住院的子宫内膜癌患者191例作为病例组,另以同期因其他良性妇科疾病行子宫切除术的194例住院患者作为对照组,比较两组临床资料差异并采用二元Logistic回归进行多因素分析。结果单因素分析显示,两组在年龄、体质量指数、高血压、糖尿病、不孕、妊娠并发症史、妊娠次数、流产次数、末次妊娠年龄以及妊娠时长(以月计)方面有统计学差异(P<0.05)。多因素分析显示,年龄、体质量指数、特定妊娠并发症(包括妊娠期高血压疾病、妊娠期糖尿病、早产)和末次妊娠年龄等因素作为最终回归方程变量,调整后的相对危险比分别为1.052、1.127、5.971和0.803(P<0.05)。结论有特定妊娠并发症史是患子宫内膜癌的独立危险因素,而末次妊娠年龄越大患子宫内膜癌的风险越低。Objective To explore the relationship between pregnancy-related factors and the risk of endometrial cancer,and to screen high-risk groups from this perspective.Methods 191 patients with endometrial cancer diagnosed by pathology and hospitalized in the Second Hospital of Shanxi Medical University from January 2022 to October 2023 were collected as a case group,and another 194 hospitalized patients who underwent hysterectomy for other benign gynecological diseases during the same period were set as a control group to compare the differences in clinical data between the two groups,and multifactorial analysis were performed using binary Logistic regression.Results Univariate analysis showed significant differences between the two groups in terms of age,body mass index,hypertension,diabetes mellitus,infertility,history of pregnancy complications,number of pregnancies,number of miscarriages,age at the last pregnancy,and duration of the pregnancy(in months)(P<0.05).Multifactorial analysis showed that age,body mass index,specific pregnancy complications(including hypertensive disorders of pregnancy,gestational diabetes mellitus,and preterm labor),and age at last gestation were the final variables included in the regression equation,which corresponded to adjusted relative hazard ratios of 1.052,1.127,5.971,and 0.803,respectively(P<0.05).Conclusion History of specific pregnancy complications is an independent risk factor for developing endometrial cancer,and the older the last pregnancy,the lower the risk of endometrial cancer.

关 键 词：妊娠并发症 妊娠次数 流产次数 每胎妊娠年龄 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]