基于皮质醇觉醒反应探讨高神经质人群基础应激表现特征  

Discussion on the basic stress characteristics of high neurotic population based on cortisol arousal response

作　　者：易爽 郑敏 韦昱 扈新刚[4] 赵燕 YI Shuang;ZHENG Min;WEI Yu;HU Xingang;ZHAO Yan(College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102299,China;Standard Room Four,National Food Safety Risk Assessment Center,Beijing 100022,China;the First Department of Encephalopathy,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100071,China)

机构地区：[1]北京中医药大学中医学院,北京102488 [2]中国疾病预防控制中心传染病预防控制所办公室,北京102299 [3]国家食品安全风险评估中心标准四室,北京100022 [4]北京中医药大学东方医院脑病一科,北京100071

出　　处：《中国医药导报》2024年第23期121-126,共6页China Medical Herald

基　　金：北京市自然科学基金资助项目(7232298);北京中医药大学基本科研业务费项目(2024-JYB-KYPT-11)。

摘　　要：目的从皮质醇觉醒反应角度探讨高神经质人群基础应激表现特征。方法于2014年9月至11月招募北京中医药大学健康女性受试者50人,借鉴心理学神经质人格的概念,将受试者分为高神经质组(28人)及低神经质组(22人),入组时通过贝克焦虑量表、贝克抑郁量表、症状自评量表、艾森人格问卷、健康调查问卷分析受试者的身心健康表现,再于受试者月经黄体中晚期进行皮质醇觉醒反应实验探讨两组在基础皮质醇水平及应激变化上的异同点。结果高神经质组贝克焦虑量表、贝克抑郁量表得分高于低神经质组,艾森克人格测验内外向倾向分量表得分低于低神经质组(P<0.05)。高神经质组症状自评量表各因子得分均高于低神经质组(P<0.05)。高神经质组叹气、怕冷、口干、疲劳、食欲改变、全身疼痛出现频率高于低神经质组(P<0.05)。不同测量时间点简单效应检验结果显示,低神经质组不同测量时间点的简单效应显著(P<0.05),多重比较发现,低神经质组醒来即刻0 min的皮质醇浓度低于晨起后30、45、60 min(P<0.05);高神经质组不同测量时间点的简单效应不显著(P>0.05)。不同组别简单效应检验结果显示,醒来的即刻0 min,晨起后45 min和晨起后60 min组别的简单效应显著(P<0.05)。醒来的即刻0 min高神经质组皮质醇浓度高于低神经质组,而在晨起后45、60 min高神经质组皮质醇浓度低于低神经质组(P<0.05)。结论高神经质人群具有基础应激高水平、应激变化减弱的特点。Objective To explore the characteristics of basic stress in high neurotic population from the perspective of cortisol arousal response.Methods Fifty healthy female subjects from Beijing University of Chinese Medicine were recruited from September to November 2014.Based on the concept of neurotic personality in psychology,the subjects were divided into high neuroticism group(28 people)and low neuroticism group(22 people).The physical and mental health performance of the subjects were analyzed by Beck anxiety inventory,Beck depression inventory,symptom checklist 90,Eysenck personality questionnaire,and health questionnaire at the time of enrollment,and then cortisol arousal response experiment was conducted in the middle and late menstrual luteum of the subjects to explore the differences and similarities in basic cortisol levels and stress changes between the two groups.Results The scores of Beck anxiety scale and Beck depression scale in high neuroticism group were higher than those in low neuroticism group,and the scores of Eysenck personality questionnaire internal and external tendency subscale were lower than those in low neuroticism group(P<0.05).The scores of symptom checklist 90 in high neuroticism group were higher than those in low neuroticism group(P<0.05).The frequency of sighing,cold fear,dry mouth,fatigue,appetite change,and whole body pain in high neuroticism group was higher than that in low neuroticism group(P<0.05).The results of simple effect test at different measuring time points showed that the simple effect at different measuring time points in the low neuroticism group was significant(P<0.05).Multiple comparisons showed that the concentration of cortisol 0 min immediately after waking up in the low neuroticism group was lower than 30,45,60 min after waking up in the morning(P<0.05).The simple effect was not significant at different time points in the high neuroticism group(P>0.05).The simple effect test results of different groups showed that the simple effect of 0 min immediately after wak

关 键 词：高神经质 皮质醇觉醒反应 基础应激 肝失疏泄 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]