监测血清泌乳素对男性精神分裂症使用利培酮的价值  

The value of monitoring serum prolactin for the use of risperidone in male schizophrenia

作　　者：张伟平 彭安萍 曾志金[1] 曹波[1] ZHANG Weiping;PENG Anping;ZENG Zhijin;CAO Bo(Psychiatry Department of the Third People’s Hospital of Jian City,Jiangxi 343000,China;Neurosurgery Department of Jian Central People’s Hospital,Jiangxi 343000,China)

机构地区：[1]江西省吉安市第三人民医院精神科,吉安343000 [2]江西省吉安市中心人民医院神经外科,吉安343000

出　　处：《上海医药》2024年第14期28-31,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：2023年度江西省吉安市科技计划项目(304254641014)。

摘　　要：目的:探讨监测血清泌乳素对男性精神分裂症使用利培酮的价值。方法:收集2023年4月—2023年10月江西省吉安市第三人民医院收治的男性精神分裂症患者60例,采用随机数字表法分成两组各30例。利培酮组接受利培酮片治疗,阿立哌唑组接受阿立哌唑片治疗,共治疗8周。比较两组患者治疗前后血清泌乳素(PRL)、阳性和阴性症状量表(PANSS)评分以及治疗后副反应量表(TESS)评分的差异。结果:利培酮组治疗后第4周末、第8周末血清PRL值均高于治疗前(P<0.05);阿立哌唑组治疗前后血清PRL值未见明显改变(P>0.05)。治疗第4周末、第8周末时,两组PANSS阳性量表、阴性量表、一般精神病理问题及总评分均低于同组治疗前(P<0.05),但两组间差异无统计学意义(P>0.05)。治疗第4周末、第8周末时,利培酮组TESS评分高于阿立哌唑组(P<0.05)。结论:使用利培酮治疗男性精神分裂症会因服药时间增加而导致血清PRL出现明显变化和副反应,临床用药时需谨慎,基层医院也可以通过PRL水平来监测患者服用利培酮的依从性及用药剂量。Objective:To explore the value of monitoring serum prolactin(PRL)in the use of risperidone in male schizophrenia.Methods:Sixty male patients with schizophrenia admitted to the Third People’s Hospital of Jian City from April 2023 to October 2023 were collected,and the random number table method was used to divide them into two groups with 30 cases in each group.The risperidone group received treatment with risperidone tablets,while the aripiprazole group received treatment with aripiprazole tablets.Both groups were treated for 8 weeks.The differences in serum PRL,positive and negative symptom scale(PANSS)scores,and treatment emergent symptom scale(TESS)scores between two groups of patients were compared before and after treatment.Results:The serum PRL value in the risperidone group at the 4th and 8th weekend of treatment were higher than those before treatment(P<0.05);there was no significant change in the serum PRL value before and after treatment in the aripiprazole group(P>0.05).On the 4th and 8th weekend of treatment,the PANSS positive and negative scales,general psychopathological problems,and total scores in the two groups were lower than those before treatment,but there were no differences in statistical significance(P<0.05).The TESS scores inf the risperidone group were higher than those in the aripiprazole group at the 4th and 8th weekend of treatment(P<0.05).Conclusion:The use of risperidone in the treatment of male schizophrenia can lead to significant changes in serum PRL and side effects due to increased duration of medication,clinical medication should be cautious,and grassroots hospitals can also monitor patient compliance and dosage of risperidone based on PRL levels.

关 键 词：男性精神分裂症 利培酮 PRL PANSS TESS 

分 类 号：R749.3[医药卫生—神经病学与精神病学]