苯扎氯铵稀释液漱口对头颈部肿瘤放疗患者口腔黏膜炎发生的影响  

Effect of benzalkonium chloride dilution gargle on incidence of oral mucositis in head and neck cancer patients undergoing radiotherapy

作　　者：胡文静 阳婷[1] 李清华[1] Hu Wenjing;Yang Ting;Li Qinghua(Jiangxi Provincial Oncology Hospital,Nanchang,Jiangxi 330029,China.)

机构地区：[1]江西省肿瘤医院,江西南昌330029

出　　处：《齐齐哈尔医学院学报》2024年第17期1693-1697,共5页Journal of Qiqihar Medical University

摘　　要：目的 探讨苯扎氯铵稀释液漱口对头颈部肿瘤(HNC)放疗患者口腔黏膜炎(OM)发生的影响。方法 选择2021年1月—2022年12月本院收治的82例HNC放疗患者作为研究对象,随机数表法分为观察组和对照组两组,每组各41例。对照组采用生理盐水漱口液漱口,观察组采用苯扎氯铵稀释液漱口。比例两组OM发生率及严重程度、OM出现所需时间、疼痛程度、生活质量、营养指标、抗菌药物使用时间及接受抗生素治疗例数。结果 观察组OM发生率及严重程度均低于对照组,差异有统计学意义(P<0.05);观察组OM出现所需时间长于对照组,放疗2周、放疗结束时视觉模拟评分法(VAS)评分低于对照组,差异有统计学意义(P<0.05);观察组放疗结束时生活质量综合评定问卷(GQOLI-74)各维度评分及总分高于对照组,差异有统计学意义(P<0.05);两组放疗结束体重、体质量指数(BMI)、血红蛋白(Hb)、白蛋白(ALB)水平均低于放疗前,差异有统计学意义(P<0.05);观察组放疗结束体重、BMI、Hb及ALB水平高于对照组,差异有统计学意义(P<0.05);观察组抗菌药物使用时间短于对照组,接受抗生素治疗患者占比少于对照组,差异有统计学意义(P<0.05)。结论 采用苯扎氯铵稀释液漱口防治OM效果良好,有利于降低HNC放疗患者OM发生率,减轻患者疼痛程度及OM严重程度,延缓OM的发生,改善营养指标,减少抗菌药物使用率,缩短抗菌药物使用时间,提高患者生活质量,可为HNC放疗患者OM的防治提供指导。Objective To investigate the impact of benzalkonium chloride dilution gargle on the development of oral mucositis(OM)in head and neck cancer(HNC)patients receiving radiotherapy.Methods Eighty-two HNC patients undergoing radiotherapy at our hospital from January 2021 to December 2022 were randomly assigned to either the observation group or the control group,with 41 patients in each group.The control group used normal saline for gargling,while the observation group used a benzalkonium chloride dilution solution.The incidence and severity of OM,time to OM onset,pain levels,quality of life,nutritional indicators,duration of antimicrobial use,and the number of patients receiving antibiotic treatment were compared between the two groups.Results The incidence and severity of OM in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The time required for OM occurrence in the observation group was longer than that in the control group;the score of visual analogue scale(VAS)of the observation group were higher than the control group at two weeks of radiotherapy and at the end of radiotherapy,the differences were statistically significant(P<0.05).The scores of each dimension and total scores of GQOLI-74 were higher in the observation group than in the control group at the end of radiotherapy,with statistical significance(P<0.05).After radiotherapy,the levels of body weight,body mass index(BMI),hemoglobin(Hb)and albumin(ALB)in two groups were lower than those before radiotherapy,and the differences were statistically significant(P<0.05).The levels of body weight,BMI,Hb and ALB in the observation group were higher than those in the control group after radiotherapy,and the differences were statistically significant(P<0.05).The observation group had a significantly lower incidence and severity of OM compared to the control group(P<0.05).The time to OM onset was longer in the observation group,and the visual analog scale(VAS)scores at two weeks and at the end of radiot

关 键 词：头颈部肿瘤 放疗 苯扎氯铵稀释液漱口 生理盐水漱口液漱口 口腔黏膜炎 

分 类 号：R781.5[医药卫生—口腔医学]