TACE联合碘-125粒子治疗多中心型肝癌的临床效果  

Clinical efficacy of TACE combined with iodine-125 particles in the treatment of multicentric hepatocellular carcinoma

作　　者：游琴章 丘博文[1] 吴伟宝 YOU Qinzhang;QIU Bowen;WU Weibao(Department of Interventional,the Second Hospital of Longyan,Longyan 364000,China)

机构地区：[1]龙岩市第二医院介入科,龙岩364000

出　　处：《华夏医学》2024年第3期186-191,共6页Acta Medicinae Sinica

基　　金：龙岩市科技计划项目(2022LYF17053)。

摘　　要：目的探究经导管动脉化疗栓塞(TACE)联合碘-125粒子治疗多中心型肝癌的效果。方法选取60例多中心型肝癌患者,随机分为两组,对照组采用TACE进行治疗,观察组采用TACE和碘-125粒子进行治疗。比较两组的临床疗效、甲胎蛋白(AFP)以及肝功能指标。结果治疗前,两组各项指标比较,均无统计学差异(P>0.05)。治疗后,观察组治疗有效率高于对照组,AFP、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)水平均低于对照组,以上差异均具有统计学意义(P<0.05)。结论TACE联合碘-125粒子治疗多中心型肝癌可有效改善肝功能指标,具有较好的临床治疗效果。Objective To investigate the clinical efficacy of transcatheter arterial chemoembolization(TACE)combined with iodine-125 particles in the treatment of multicentric hepatocellular carcinoma.Methods 60 patients with multicenter liver cancer were selected and randomly divided into two groups.The control group were treated with TACE,while the observation group were treated with TACE and iodine-125 particles.The clinical efficacy,alpha fetoprotein(AFP),and liver function indicators were compared between two groups.Results Before treatment,there was no statistically significant difference in each indicator between two groups(P>0.05).After treatment,the effective rate in the observation group was higher than that in the control group,and the levels of AFP,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBIL)were all lower in the observation group than those in the control group,showing a statistically significant difference(P<0.05).Conclusion TACE combined with iodine-125 particles can effectively improve liver function indicators in the treatment of multicentric hepatocellular carcinoma,and has a good clinical therapeutic effect.

关 键 词：经导管动脉化疗栓塞 碘-125粒子 多中心型肝癌 临床疗效 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]