骨形态蛋白2调控牙囊成骨分化在牙齿萌出中作用的研究进展  

Research progress on the role of bone morphogenetic protein 2 in regulating dental sac osteogenic differentiation during tooth eruption

作　　者：刘星宇 秦晗 LIU Xingyu;QIN Han(Department of Stomatology,Lianyungang Clinical Medical College,Nanjing Medical University,Jiangsu Province,Lianyungang222002,China)

机构地区：[1]南京医科大学连云港临床医学院口腔科,江苏连云港222002

出　　处：《中国医药导报》2024年第21期46-49,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81500893);江苏省连云港市“521工程”资助项目(LYG06521202362)。

摘　　要：牙囊作为牙齿萌出的必要器官,在诱导成骨/破骨细胞分化、促进萌出通道形成方面具有重要作用。骨形态蛋白2(BMP2)是一种多效形态因子,具有高度骨诱导活性,主要通过自分泌或旁分泌形式介导牙囊细胞向成骨细胞分化。近年来,关于BMP2通过调控牙囊成骨分化促进牙槽骨改建,保证牙齿萌出通道正常形成的相关研究日益引发众多学者的关注,然而具体机制尚不明了。本文通过对BMP2生物学性能及其与多种信号通路交互作用共同调节牙囊成骨分化的可能机制进行述评,旨在从骨代谢角度拓展牙齿萌出过程中分子调控机制的研究及牙齿萌出障碍的防治提供新的理论依据。As a necessary organ for tooth eruption,dental sac play an important role in inducing osteogenic/osteoclast differentiation and promoting the formation of eruption channels.Bone morphogenetic protein 2(BMP2)is a multifunctional morphological factor with high osteoinductive activity,mainly mediating the differentiation of dental sac cell into osteoblasts through autocrine or paracrine forms.In recent years,research on BMP2 promoting alveolar bone remodeling by regulating dental sac osteogenic differentiation and ensuring the normal formation of tooth eruption channels has increasingly attracted the attention of many scholars.However,the specific mechanism is still unclear.This article reviews biological properties of BMP2 and its possible mechanism of co-regulating dental sac osteogenic differentiation through its interaction with multiple signaling pathways.The aim is to provide new theoretical basis for expanding the research on molecular regulatory mechanisms during tooth eruption from the perspective of bone metabolism and preventing and treating tooth eruption disorders.

关 键 词：骨形态蛋白2 牙囊 成骨分化 牙齿萌出 

分 类 号：R781[医药卫生—口腔医学]