细胞外囊泡在去势抵抗性前列腺癌中的应用及研究进展  

Application and research progress of extracellular vesicles in castration-resistant prostate cancer

作　　者：黄劲峰 任瑞民[1] HUANG Jinfeng;REN Ruimin(Department of Urology,Third Hospital of Shanxi Medical UniversityShanxi Bethune Hospital,Shanxi Province,Taiyuan030032,China)

机构地区：[1]山西医科大学第三医院山西白求恩医院泌尿外科,山西太原030032

出　　处：《中国医药导报》2024年第22期59-61,共3页China Medical Herald

基　　金：中央引导地方科技发展资金项目(YDZJSX 20231A066)。

摘　　要：前列腺癌是男性中第二常见的恶性肿瘤,过去10年间,前列腺癌生物标志物的研究取得显著进展,尤其在尿液和血液检测领域。液体活检是一种微创方法,通过检测循环肿瘤细胞、细胞游离DNA和细胞外囊泡(EVs)中的癌症相关分子,揭示癌症的异质性和获得耐药性。EVs作为细胞衍生的囊泡,内含核酸、蛋白质和脂质等多种分子,可从癌症患者的尿液、血浆和血清中分离。EVs的分泌不仅促进癌症的进展、转移和耐药性,还可作为诊断高级别前列腺癌及预测去势抵抗性前列腺癌疾病进展的有效工具。本文综述EVs在去势抵抗性前列腺癌诊断和疾病进展预测中的应用,并探讨其在癌症进程中的生物学功能。Prostate cancer is the second most common malignancy in men.Over the past decade,significant progress has been made in prostate cancer biomarker research,particularly in urine and blood tests.Liquid biopsy is a minimally invasive method that detects cancer-related molecules in circulating tumor cells,cell-free DNA,and extracellular vesicles(EVs),revealing cancer heterogeneity and acquired resistance.EVs,as cell-derived vesicles,contain various molecules such as nucleic acids,proteins,and lipids,and can be isolated from urine,plasma,and serum of cancer patients.The secretion of EVs not only promotes cancer progression,metastasis,and drug resistance,but also serves as an effective tool for diagnosing high-grade prostate cancer and predicting the progression of castration-resistant prostate cancer.This article reviews application of EVs in the diagnosis and disease progression prediction of castration-resistant prostate cancer,and explores their biological functions in cancer progression.

关 键 词：细胞外囊泡 去势抵抗性前列腺癌 外泌体 生物标志物 治疗靶点 

分 类 号：R737.25[医药卫生—肿瘤]