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作 者:梁远珊 王志军 付江泉 喻国冻 周方伟 张田 LIANG Yuanshan;WANG Zhijun;FU Jiangquan;YU Guodong;ZHOU Fangwei;ZHANG Tian(Department of Otolaryngology Head and Neck Surgery,Affiliated Hospital of Guizhou Medical University,Guizhou Province,Guiyang550025,China;Department of Emergency Critical Care Medicine,Affiliated Hospital of Guizhou Medical University,Guizhou Province,Guiyang550025,China)
机构地区:[1]贵州医科大学附属医院耳鼻咽喉头颈外科,贵州贵阳550025 [2]贵州医科大学附属医院急诊重症医学科,贵州贵阳550025
出 处:《中国医药导报》2024年第22期62-68,共7页China Medical Herald
基 金:贵州省科技计划项目(黔科合基础-ZK[2023]一般365);贵州省贵阳市科技计划项目(筑科合同[2022]-4-2-7号);贵州省科技厅基金项目(黔科合基础-ZK[2023]一般400)。
摘 要:随着综合治疗的不断完善,鼻咽癌的死亡率显著降低,患者的生存机会得到提升。放疗抵抗或化疗耐药患者的治疗效果较差,因此迫切需要研究鼻咽癌对放疗敏感性和化疗耐药的潜在分子机制,寻找新的治疗靶点。长链非编码RNA在鼻咽癌的发生和发展中发挥重要作用,越来越多研究表明其是影响鼻咽癌放化疗耐药性的关键调节因子。通过选择性地调控长链非编码RNA功能,可增强鼻咽癌细胞对放化疗的反应,为基于长链非编码RNA相关基因治疗的创新性抗肿瘤方法提供新途径。本文综述长链非编码RNA在鼻咽癌放疗敏感性和化疗耐药机制方面的研究进展。With the continuous improvement of comprehensive treatment,the mortality rate of nasopharyngeal carcinoma has been significantly reduced,and the survival opportunity of patients has been improved.Treatment effect of patients with radiotherapy resistance or chemotherapy resistance is poor.Therefore,it is urgent to study the potential molecular mechanism of radiotherapy sensitivity and chemotherapy resistance of nasopharyngeal carcinoma,and to find new therapeutic targets.Long non-coding RNA plays an important role in the occurrence and development of nasopharyngeal carcinoma.More and more studies have shown that it is a key regulator of radiochemotherapy resistance in nasopharyngeal carcinoma.By selectively regulating the function of long non-coding RNA,the response of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy can be enhanced,which provides a new way for innovative anti-tumor methods based on long non-coding RNA-related gene therapy.This article reviews the research on the mechanism of long non-coding RNA in radiotherapy sensitivity and chemotherapy resistance of nasopharyngeal carcinoma.
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