肠道微生物群与肝脏再生研究进展  

Intestinal microbiota and liver regeneration:progress in research

作　　者：卫彦芳[1] 闫虹佑 许翠萍[1] WEI Yanfang;YAN Hongyou;XU Cuiping(The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030000,China;不详)

机构地区：[1]山西医科大学第一医院,山西太原030000 [2]山西医科大学

出　　处：《中国微生态学杂志》2024年第7期865-868,共4页Chinese Journal of Microecology

摘　　要：肝脏是一个具有强大再生能力的器官,其再生过程受多种因素的调控。在肝部分切除术及肝移植术后,肝脏能否恢复正常的形态及功能是判断手术是否成功的关键。因此,明确调控肝脏再生的因素对促进肝脏再生具有至关重要的作用。研究发现,人体庞大且复杂的肠道微生物群及其代谢产物在肝脏再生中发挥着重要作用,其中肠源性内毒素、与肠道微生物群相关的胆汁酸和肠道细菌代谢产物(如短链脂肪酸和色氨酸)等均参与肝脏再生,但其确切机制尚不清楚。本文就肠道微生物群及其代谢产物与肝脏再生的研究进展作一综述,以期为临床工作及相关研究提供参考。The liver is a powerful regenerative organ and the regenerative process is regulated by several factors.After partial hepatectomy and liver transplantation,the ability of the liver to return to normal form and function is critical to the success of the procedure.Therefore,identifying the factors that regulate liver regeneration plays a crucial role in promoting liver regeneration.It has been found that the large and complex intestinal microbiota and its metabolites play a significant role in liver regeneration,among which intestinal endotoxemias,bile acids associated with intestinal microbiota and intestinal bacterial metabolites,such as short-chain fatty acids and tryptophan metabolites,are involved in liver regeneration.However,the exact mechanism is not clear.In this paper,we review the progress in research on intestinal microbiota and its metabolites and liver regeneration to provide a reference for clinical work and related research.

关 键 词：肝脏再生 肠源性内毒素 肠道微生物群 胆汁酸 

分 类 号：R575[医药卫生—消化系统]