褪黑素在周围神经损伤修复中的应用  

Application of melatonin in peripheral nerve injury repair

作　　者：林立宁 孙谋远 王慧明[1] LIN Lining;SUN Mouyuan;WANG Huiming(Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang University School of Stomatology,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Bio-medical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and De-vices of Zhejiang Province,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属口腔医院,浙江大学口腔医学院,浙江省口腔疾病临床医学研究中心,浙江省口腔生物医学研究重点实验室,浙江大学癌症研究院,口腔生物材料与器械浙江省工程研究中心,浙江杭州310000

出　　处：《口腔医学》2024年第8期617-623,共7页Stomatology

基　　金：国家自然科学基金国际(地区)合作与交流项目(82020108011);浙江省科技计划项目(2023C03071);中国博士后科学基金面上项目(2023M743009)。

摘　　要：因外伤、肿瘤等原因引起的口腔颌面部周围神经损伤日益常见,其造成的感觉与运动功能障碍严重困扰着患者的生活。损伤后的周围神经虽具有一定的自我修复能力,但受限于损伤程度以及机体自身状况,大间距周围神经缺损仍需手术干预,且术后患者神经功能的恢复情况并不理想,这与损伤后局部存在的炎性微环境密切关系。褪黑素作为体内松果体合成的化合物,具有良好的抗炎作用,并能调节周围神经再生过程中的关键细胞的行为与命运,在神经组织工程中具有良好的应用前景。本文综述了褪黑素的合成与代谢过程,并对其促进周围神经再生的作用机制、应用现状以及在颌面部疾病中的潜在应用进行了总结,为周围神经缺损修复提供了一种新的思路。The increasing incidence of peripheral nerve injuries brought on by trauma or tumors is substantially interfering with peoples lives due to the causal sensory and motor dysfunctions.Peripheral nerves have some self⁃repair ability after injury,but they are limited by the degree of injury and the bodys condition.The postoperative recovery of nerve function in patients is not satisfactory,which is closely related to the local inflammatory microenvironment after injury.Melatonin,a compound naturally synthesized in the pineal gland,protects peripheral nervous system cells from oxidative inflammation after injury and regulates their behavior and fate.Therefore,it has good application prospect in nerve tissue engineering.In this paper,we review the synthesis,metabolic processes un⁃derlying melatonin,mechanism of action as well as the current status of its application in peripheral nerve regeneration as well as poten⁃tial application for oral diseases.In this way,it further provides a new idea for the clinical treatment of peripheral nerve injury.

关 键 词：周围神经损伤 褪黑素 抗炎 细胞行为与命运调控 机制 

分 类 号：R782.4[医药卫生—口腔医学]