中药通过调控核因子κB信号通路介导炎症反应防治肠粘连的研究进展  

Research progress on the prevention and treatment of intestinal adhesion by regulating nuclear factor kappa B signaling pathway mediated inflammatory response in traditional Chinese medicine

作　　者：李雪 何运胜 刘洋 廖烽丸 陈鑫明 廖开丽 LI Xue;HE Yunsheng;LIU Yang;LIAO Fengwan;CHEN Xinming;LIAO Kaili(Department of General Surgery,Mianyang Hospital Affiliated to Chengdu University of Traditional Chinese Medicine,Sichuan Province,Mianyang621000,China)

机构地区：[1]成都中医药大学附属绵阳医院普通外科,四川绵阳621000

出　　处：《中国医药导报》2024年第20期51-56,共6页China Medical Herald

基　　金：四川省中医药管理局科学技术研究专项课题(2021MS213);成都中医药大学附属绵阳医院/绵阳市中医医院校院联合创新基金项目(LH202402008)。

摘　　要：肠粘连是腹部术后常见的并发症之一,核因子κB(NF-κB)信号通路与肠粘连的发生和发展密切相关,中药通过调控NF-κB信号通路抗炎逐渐成为防治肠粘连研究领域的新靶点。长期的临床研究及实践、中药药理学等相关研究表明,中药可通过介导炎症通路调控炎症细胞因子的表达,在防治肠粘连的多个病理环节均可发挥重要作用。本文回顾近5年相关文献,对通过NF-κB信号通路发挥抗炎作用以抗粘连的中药药理机制和功效等进行系统分析和总结,以期为深入研究中药在防治腹部术后肠粘连的应用中提供更多参考。Intestinal adhesion is one of the common complication after abdominal surgery,and nuclear factorκB(NF-κB)signaling pathway is closely related to occurrence and development of intestinal adhesion.Traditional Chinese medicine has gradually become a new target in the field of preventing and treating intestinal adhesion by regulating NF-κB signaling pathway for anti-inflammatory effect.Long term clinical research and practice,as well as related studies on traditional Chinese medicine pharmacology,have shown that traditional Chinese medicine can regulate the expression of inflammatory cytokines by mediating inflammatory pathway,and play an important role in preventing and treating multiple pathological links of intestinal adhesion.This article reviews relevant literature in the past five years,systematically analyzes,and summarizes pharmacological mechanisms and efficacy of traditional Chinese medicine that exert anti-inflammatory effects through the NF-κB signaling pathway to prevent adhesion,with a view to providing more references for in-depth research on the application of traditional Chinese medicine in the prevention and treatment of postoperative intestinal adhesion in the abdomen.

关 键 词：核因子ΚB 炎症通路 肠粘连 中药防治 

分 类 号：R574[医药卫生—消化系统]