智能水凝胶在生物医药领域的应用进展  

Research advances of applying intelligent hydrogels in the field of biomedicine

作　　者：段秀红 马华 尚宏周 刘汉达 魏丁香 乔宁 DUAN Xiuhong;MA Hua;SHANG Hongzhou;LIU Handa;WEI Dingxiang;QIAO Ning(College of Pharmacy,North China University of Science&Technology,Hebei Tang-shan 063210,China;College of Material Science&Engineering,North China University of Science&Technology,Hebei Tang-shan 063210,China)

机构地区：[1]华北理工大学药学院,河北唐山063210 [2]华北理工大学材料科学与工程学院,河北唐山063210

出　　处：《中国医院药学杂志》2024年第16期1950-1955,1959,共7页Chinese Journal of Hospital Pharmacy

基　　金：河北省教育厅科学技术研究项目(编号:JYG2020002);唐山市功能高分子材料基础创新团队项目(编号:21130201D)。

摘　　要：水凝胶是一种具有优异亲水性、柔韧性和溶胀特性的三维网络立体结构的高分子材料,并且具有良好的生物相容性和可降解性。因此,水凝胶在载药输送、组织支架等生物医学领域有极大的应用潜能。该研究总结了国内外近几年文献,介绍了温度响应型、pH响应型、氧化还原响应型、酶响应型、电响应型和多重响应型水凝胶,重点阐述了水凝胶在组织工程、药物载体、敷料、传感器、3D细胞培养方面的应用,并对其发展前景作出了展望。As a polymer material with a three-dimensional network structure,hydrogel has excellent properties of hydrophilic⁃ity,flexibility and swelling.Also it has decent biocompatibility and degradability.Therefore hydrogels have great potential appli⁃cations in such biomedical fields as drug delivery and tissue scaffolds.Summarizing the latest domestic and foreign literatures,this review introduced different types of hydrogels responsive to temperature,pH,redox,enzyme,electricity and multiple factors.The applications of hydrogels in biomedicine included tissue engineering,drug carrier,dressing,sensor and 3D cell culture.

关 键 词：水凝胶 响应刺激 生物医药 

分 类 号：R914[医药卫生—药物化学]