新型胃泌素释放肽受体靶向PET分子探针应用于肿瘤显像的研究进展  

Research progress of novel gastrin releasing peptide receptor-targeted PET molecular probes for tumor imaging

作　　者：吴俊[1,2] 苗增利 WU Jun;MIAO Zengli(The Second People's Hospital of Wuxi,Nanjing Medical University,Wuxi 214043,China;Department of Neurosurgery,The Second People's Hospital of Wuxi,Wuxi 214043,China)

机构地区：[1]南京医科大学附属无锡市第二人民医院,江苏无锡214043 [2]无锡市第二人民医院神经外科,江苏无锡214043

出　　处：《分子影像学杂志》2024年第8期881-886,共6页Journal of Molecular Imaging

基　　金：无锡市卫健委重大项目(Z202324)。

摘　　要：胃泌素释放肽受体(GRPR)是一种属于铃蟾肽受体家族的G蛋白偶联受体,主要分布于整个胃肠道和中枢神经系统,通过与其配体胃泌素释放肽结合发挥生物学作用。近年研究发现,GRPR在许多恶性肿瘤中过度表达并参与恶性肿瘤的发生发展,如乳腺癌、前列腺癌、肺癌、胰腺癌和多形性胶质母细胞瘤等。正电子发射计算机断层扫描(PET)是一种通过检测放射性标记物质在人体内部的分布和浓度来提供图像的医学成像技术,能够提供更全面、准确的诊断信息。已有研究表明靶向GRPR的PET显像在多种恶性肿瘤的诊断、治疗监测和预后评估等方面发挥重大作用,因此,开发特异性强、亲和性高的GRPR探针对肿瘤的诊断与治疗意义重大。本文针对已报道的新型GRPR靶向PET分子探针的种类及肿瘤显像的应用展开综述,以期为GRPR靶向PET分子探针的研发及临床转化提供新思路和新方向。Gastrin-releasing peptide receptor(GRPR)is a G protein-coupled receptor belonging to the bombesin receptor family,mainly distributed throughout the gastrointestinal tract and central nervous system,exerting biological functions by binding with its ligand gastrin-releasing peptide.Recent studies have found that GRPR is overexpressed in many malignant tumors and is involved in the development of malignancies such as breast cancer,prostate cancer,lung cancer,pancreatic cancer,and medulloblastoma.Positron emission tomography(PET)is a medical imaging technique that provides images by detecting the distribution and concentration of radiolabeled substances within the body,offering more comprehensive and accurate diagnostic information.Existing research has shown that GRPR-targeted PET imaging plays a significant role in the diagnosis,treatment monitoring,and prognosis assessment of various malignant tumors.Therefore,the development of highly specific and high-affinity GRPR probes is of great significance for the diagnosis and treatment of tumors.This article provides a review of the types of novel GRPR-targeted PET molecular probes reported and their applications in tumor imaging,aiming to offer new ideas and directions for the research and clinical translation of GRPR-targeted PET molecular probes.

关 键 词：胃泌素释放肽受体 正电子发射断层扫描成像 分子探针 肿瘤 

分 类 号：R730.44[医药卫生—肿瘤]