China antimicrobial resistance surveillance network for pets(CARPet),2018 to 2021  

作　　者：Shizhen Ma Siyu Chen Yanli Lyu Wei Huang Yang Liu Xukun Dang Qi An Yu Song Ying Jiao Xiaowei Gong Qian Wang Yuqian Shi Yifei Li Dongyan Shao Zhiyu Zou Kaiying Zhang Luxin Li Gege Zhang Tengkun Yang Lu Yang Zhenbiao Zhang Haixia Zhang Yanyun Chen Gebin Li Yongqiang Wang Lu Wang Zhangqi Shen Congming Wu Fupin Hu Stefan Schwarz Yang Wang Zhaofei Xia Jianzhong Shen 

机构地区：[1]Key Laboratory of Animal Antimicrobial Resistance Surveillance,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China [2]Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China [3]Department of Clinical Veterinary Medicine,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China [4]Clinical Laboratory Diagnostic Center,China Agricultural University Veterinary Teaching Hospital,Beijing,China [5]Department of Preventive Veterinary Medicine,College of Veterinary Medicine,China Agricultural University,Beijing,China [6]Shanxi Key Laboratory for Modernization of TCVM,College of Veterinary Medicine,Shanxi Agricul-tural University,Taiyuan,China [7]Ruichen Pet Hospital Group Co.,Ltd,Beijing,China [8]Qisheng(Tianjin)Pet Hospital Management Co.,Ltd,Tian Jin,China [9]Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai,China [10]Institute of Microbiology and Epizootics,Centre for Infection Medicine,Department of Veterinary Medicine,Freie Universität Berlin,Berlin,Germany [11]Veterinary Centre for Resistance Research(TZR),Freie Universität Berlin,Berlin,Germany.

出　　处：《One Health Advances》2023年第1期298-310,共13页全健康进展（英文）

基　　金：financially supported by the National Key Research and Development Program of China(2022YFD1800400);Beijing Municipal Science and Technology Project(Z171100001517008).

摘　　要：China Antimicrobial Resistance Surveillance Network for Pets(CARPet)was established in 2021 to monitor the resist-ance profiles of clinical bacterial pathogens from companion animals.From 2018 to 2021,we recovered and tested 4,541 isolates from dogs and cats across 25 Chinese provinces,with Escherichia coli(18.5%)and Staphylococcus pseudintermedius(17.8%)being the most predominant bacterial species.The Enterobacterales were highly susceptible to tigecycline,meropenem,colistin,and amikacin(70.3%-100.0%),but showed moderate resistance to ampicillin,ceftriaxone,doxycycline,florfenicol,levofloxacin,enrofloxacin,and trimethoprim-sulfamethoxazole(29.3%-56.7%).About 66.3%of Acinetobacter spp.were resistant to florfenicol,with relatively low resistance to another 11 antibiot-ics(1.2%-23.3%).The Pseudomonas spp.showed high susceptibility to colistin(91.7%)and meropenem(88.3%).The coagulase-positive Staphylococcus spp.showed higher resistance rates to most antimicrobial agents than coagulase-negative Staphylococcus isolates.However,over 90.0%of Staphylococcus spp.were susceptible to linezolid,dapto-mycin and rifampin,and no vancomycin-resistant isolates were detected.E.faecium isolates demonstrated higher resistance rates to most antimicrobial agents than E.faecalis isolates.Streptococcus spp.isolates showed low resistance to most antimicrobial agents except for doxycycline(78.2%)and azithromycin(68.8%).Overall,the tested clinical isolates showed high rates of resistance to commonly used antimicrobial agents in companion animals.Therefore,it is crucial to strengthen the monitoring of bacterial resistance in pets.By timely and effectively collecting,analyzing,and reporting antimicrobial resistance dynamics in pets,the CARPet network will become a powerful platform to provide scientific guidance for both pet medical care and public health.

关 键 词：Antimicrobial resistance Surveillance network PETS China Susceptibility testing 

分 类 号：S85[农业科学—兽医学]