口腔黏膜下纤维性变的治疗研究进展  

Research progress of the treatment of oral submucosal fibrous

作　　者：陈灵[1] 杜永秀[1] 徐普[1] CHEN Ling;DU Yongxiu;XU Pu(Hainan Provincial Stomatology center,Haikou Affiliated Hospital of Central South University Xiangya School of Medicine,Haikou 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院海南省口腔医学中心,海口市570208

出　　处：《河北医药》2024年第17期2675-2679,2685,共6页Hebei Medical Journal

基　　金：海南省重大科技计划项目(编号:ZDKJ2021039)。

摘　　要：口腔黏膜下纤维性变(OSF)是一种慢性、潜伏性疾病,被归类为口腔潜在恶性疾病,是一个全球性和区域性的公共卫生问题。它被认为是一种多因素疾病,如咀嚼槟榔、微量元素紊乱和遗传易感性等。本文回顾总结近年来国内外治疗OSF的各种方法,包括药物治疗、手术治疗、物理治疗等,以上治疗方法主要是减轻疾病的体征和症状,尚缺乏单一有效的治疗方法。此外,有部分研究者提出新的治疗方法-干细胞治疗,但是观察病例量较少,疗效和安全性有待进一步研究。Oral submucous fibrosis(OSF)is a chronic,latent disease classified as oral potentially malignant disorder,which is a global and regional public health problem.It is considered to be a multifactorial disease,and its inducements include chewing areca nut,micronutrient disorders genetic predisposition,etc.In this paper,various methods for the treatment of OSF in recent years at home and abroad are reviewed and summarized,covering drug therapy,surgical therapy,physical therapy,etc.The above methods are mainly to reduce the symptoms of this disease.The single effective method to treat OSF is still unreported.It is noteworthy that some researchers have proposed a new treatment-Stem cell therapy,while the number of observed cases is small,and its efficacy and safety need to be further studied.

关 键 词：口腔黏膜下纤维性变 治疗 张口受限 干细胞治疗 

分 类 号：R781.5[医药卫生—口腔医学]