多层螺旋CT增强扫描联合EGFR突变检测在肺癌患者中的诊断效果  

Diagnostic Effect of Multi-slice Spiral CT Enhanced Scan Combined with EGFR Mutation Detection in Patients with Lung Cancer

作　　者：张宇 甘志兰 ZHANG Yu;GAN Zhilan(Department of Radiology,the Second People's Hospital of Yichun City,Yichun 336000,China)

机构地区：[1]宜春市第二人民医院放射科,江西宜春336000

出　　处：《中国医学创新》2024年第23期117-121,共5页Medical Innovation of China

摘　　要：目的:探讨多层螺旋CT(MSCT)增强扫描联合表皮生长因子受体(EGFR)突变检测在肺癌患者中的诊断效果。方法:选取2021年1月—2023年1月宜春市第二人民医院经组织病理学检查确诊的80例肺癌患者(肺癌组)和50例肺良性病变患者(肺良性病变组)为研究对象,均行MSCT增强扫描检查,并采用xTAG70plex液相芯片技术检测EGFR突变情况。比较两组MSCT增强扫描征象、EGFR突变阳性率,并分析MSCT增强扫描联合EGFR突变检测对肺癌的诊断效能。结果:肺癌组MSCT增强扫描征象中肺组织边界不清晰、毛刺征、血管集束征、支气管充气征、胸膜凹陷征比例均高于肺良性病变组(P<0.05);两组病灶位置、病灶形状及内部结构比较,差异均无统计学意义(P>0.05)。肺良性病变组EGFR突变阳性率为6.00%(3/50),肺癌组为63.75%(51/80),肺癌组EGFR突变阳性率高于肺良性病变组(χ^(2)=42.257,P<0.05)。肿瘤最大直径≥5 cm患者EGFR突变阳性率高于<5 cm患者,Ⅲ、Ⅳ期患者EGFR突变阳性率高于Ⅰ、Ⅱ期患者,低分化患者EGFR突变阳性率高于中、高分化患者,淋巴结转移患者EGFR突变阳性率高于无淋巴结转移患者(P<0.05);两组不同病理类型肺癌EGFR突变阳性率比较,差异无统计学意义(P>0.05)。受试者操作特征(ROC)曲线显示,MSCT增强扫描联合EGFR突变检测诊断肺癌的敏感度为93.7%,特异度为92.0%,均高于MSCT增强扫描、EGFR突变检测的78.5%、87.2%和76.0%、78.5%。结论:MSCT增强扫描联合EGFR突变检测能提高肺癌诊断效能,可对肺癌临床筛查诊断、制订治疗方案提供一定的参考依据。Objective:To explore the diagnostic effect of multi-slice spiral CT(MSCT)enhanced scan combined with epidermal growth factor receptor(EGFR)mutation detection in patients with lung cancer.Method:A total of 80 patients with lung cancer(lung cancer group)and 50 patients with benign lung disease(benign lung disease group)confirmed by histopathological examination in the Second People's Hospital of Yichun City from January 2021 to January 2023 were selected as the study objects,and all of them underwent MSCT enhancement scan examination,and EGFR mutation were detected by xTAG70plex liquid chip technology.The signs of MSCT enhanced scan and EGFR mutation positive rate of the two groups were compared,and the diagnostic efficacy of MSCT enhanced scan combined with EGFR mutation detection in lung cancer was analyzed.Result:The proportion of lung tissue boundary unclear,spicule sign,vascular cluster sign,air bronchial sign and pleural indentation sign in MSCT enhanced scan sign of lung cancer group were higher than those of benign lung disease group(P<0.05).There were no significant differences in lesion location,lesion shape and internal structure between the two groups(P>0.05).The positive rate of EGFR mutation was 6.00%(3/50)in benign lung disease group and 63.75%(51/80)in lung cancer group,the positive rate of EGFR mutation in lung cancer group was higher than that in benign lung disease group(χ^(2)=42.257,P<0.05).The EGFR mutation positive rate in patients with maximum tumor diameter≥5 cm was higher than that in patients with<5 cm,the EGFR mutation positive rate in patients with stageⅢandⅣwas higher than that in patients with stageⅠandⅡ,the EGFR mutation positive rate in patients with low differentiation was higher than that in patients with medium and high differentiation,and the EGFR mutation positive rate in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P<0.05).There was no significant difference in the positive rate of EGFR mutation between the two gr

关 键 词：肺癌 多层螺旋CT 增强扫描 表皮生长因子受体突变 诊断效能 

分 类 号：R734.2[医药卫生—肿瘤]