基于SEER数据库分析婚姻状况对前列腺癌患者预后的影响  

Effect of marital status on the prognosis of prostate cancer patients based on SEER database

作　　者：韩瑞敏 孙力[1] 王德峰[2] 王珍 HAN Ruimin;SUN Li;WANG Defeng;WANG Zhen(School of Clinical Medicine,Hebei University of Engineering,Handan 056038,Hebei,China;Department of Endocrinology,the Affiliated Hospital of Hebei University of Engineering,Handan 056002,Hebei,China)

机构地区：[1]河北工程大学临床医学院,河北邯郸056038 [2]河北工程大学附属医院内分泌科,河北邯郸056002

出　　处：《中国现代医生》2024年第24期71-76,共6页China Modern Doctor

摘　　要：目的研究婚姻状况与前列腺癌患者预后的关系。方法从美国SEER数据库提取16815例前列腺癌患者的数据,采用Log-rank单因素和多因素Cox风险比例模型评估婚姻状况与前列腺癌患者预后的关系。结果①在不同肿瘤阶段,婚姻状况可作为肿瘤预后的独立因素;②前列腺特异性抗原(prostate-specific antigen,PSA)<10ng/ml时婚姻状况与前列腺癌的生存率相关性最强,PSA<10ng/ml、PSA10~20ng/ml不同婚姻状况的肿瘤生存率差异明显;③Gleason=7分和Gleason≥8分已婚组患者中生存曲线及5年生存率明显高于未婚组及离婚/丧偶组;④经手术治疗的患者存活时间更长,无论手术与否,已婚患者的生存率显著高于其他婚姻状况的患者;⑤本研究中不同分组情况下,已婚前列腺癌患者的死亡风险均低于其他婚姻状况的患者。结论婚姻状况在一定程度上可作为前列腺癌患者的独立预后因素,且已婚前列腺癌患者的死亡风险系数低于其他婚姻状况的患者。Objective To study the relationship between marital status and prognosis of prostate cancer patients.Methods A total of 16815 prostate cancer patients’data were extracted from the US SEER database,and the relationship between marital status and the prognosis of prostate cancer patients was assessed by using Log-rank unifactorial and multifactorial Cox risk-proportional models.Results①At different stages of cancer,marital status can serve as an independent factor for tumor prognosis;②When the prostate-specific antigen(PSA)<10ng/ml,the strongest correlation between marital status and prostate cancer survival rate was observed.There was a significant difference in tumor survival rate between different marital statuses with PSA<10ng/ml and PSA levels between 10-20ng/ml;③The survival curve and 5-year survival rate of patients with Gleason=7 points and Gleason≥8 points in married group were significantly higher than those in unmarried group and divorced/widowed group;④Patients who undergo surgical treatment have a longer survival time,and regardless of whether surgery is performed or not,the survival rate of married patients is significantly higher than that of patients with other marital statuses;⑤In this study,the mortality risk of married prostate cancer patients was lower than that of patients with other marital statuses under different grouping conditions.Conclusion Marital status can be used as an independent prognostic factor for prostate cancer patients to a certain extent,and the mortality risk coefficient of married prostate cancer patients is lower than that of patients with other marital status.

关 键 词：前列腺癌 婚姻状况 预后 SEER数据库 

分 类 号：R737.25[医药卫生—肿瘤]