基于肠肝轴理论从肝脾论治肝纤维化研究进展  

Research Progress of Treating Liver Fibrosis from the Perspective of Liver and Spleen Based on the Theory of Gut-liver Axis

作　　者：王姝婷 徐晓梅[2] WANG Shuting;XU Xiaomei(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250355,China;Department of Hepatology,Linyi Hospital of Traditional Chinese Medicine,Shandong Province,Linyi 276000,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250355 [2]临沂市中医医院肝病科,山东临沂276000

出　　处：《中国中医药现代远程教育》2024年第20期102-104,共3页Chinese Medicine Modern Distance Education of China

摘　　要：肝纤维化特效治疗方法的缺少,促进了相关研究的持续活跃。目前可得的临床证据和源于基础领域的相关研究进展表明,肠道微生物菌群的生态失调、黏膜免疫功能受损和炎性反应是肝纤维化发生发展的重要因素。调节肠道菌群是治疗肝纤维化的重要策略和靶位之一,具有良好的前景。肠肝轴的作用与中医肝脾生理功能类似,众多研究从肠肝轴理论出发,探讨从中医肝脾论治肝纤维化的相关机制,并取得了良好的临床效果。文章通过查阅相关文献报道,以期找到治疗肝纤维化的新思路和研究方向,并为今后此领域的中医药深入研究提供重要的参考。Lack of specific treatment for liver fibrosis promotes continued active research.The available clinical evidence and related research progress from basic fields showed that the ecological imbalance of intestinal flora,the impairment of mucosal immune func⁃tion and inflammatory response are important factors in the development of liver fibrosis.Regulation of intestinal flora is one of the im⁃portant strategies and therapeutic targets for the treatment of liver fibrosis,and has good prospects.In the theoretical system of tradi⁃tional Chinese medicine,the role of the gut-liver axis is similar to the physiological functions of the liver and spleen.Based on the theory of gut-liver axis,many studies have explored the related mechanism of traditional Chinese medicine in the treatment of liver fi⁃brosis from liver and spleen,and achieved good clinical efficacy.This paper aims to find out new ideas and research directions for the treatment of liver fibrosis and provide important references for the further research of traditional Chinese medicine in this field.

关 键 词：肝纤维化 肠肝轴 肝病实脾 综述 

分 类 号：R259[医药卫生—中西医结合]