阿米替林治疗肠易激综合征的效果  

Effects of amitriptyline in the treatment of irritable bowel syndrome

作　　者：慕志杰 张凡 MU Zhijie;ZHANG Fan(Department of Gastroenterology,Wuzhi Jimin Hospital,Jiaozuo 454950,China;Department of Gastroenterology,Zhengzhou Second Hospital,Zhengzhou 450000,China)

机构地区：[1]武陟济民医院消化内科,焦作454950 [2]郑州市第二人民医院消化内科,郑州450000

出　　处：《华夏医学》2024年第4期89-94,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ20220104)。

摘　　要：目的观察阿米替林辅助治疗肠易激综合征(IBS)的临床效果。方法选取110例IBS患者作为研究对象,采用随机数字表法将患者分为两组,每组55例。对照组按照常规剂量阿米替林辅助治疗,实验组采用小剂量阿米替林辅助治疗,比较两组治疗效果及用药安全性。结果在不同用药剂量下,试验组的上腹疼痛、腹部烧灼、食欲低下症状积分均略高于对照组,但差异无统计学意义(P>0.05);试验组胃泌素(GAS)、胃动素(MLT)、胃蛋白酶Ⅰ(PGⅠ)、胃蛋白酶Ⅱ(PGⅡ)的水平均略低于对照组(P>0.05);试验组餐后慢波值略低于对照组,胃电频率、胃电紊乱节律百分比略高于对照组(P>0.05)。试验组的药物相关不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论阿米替林能通过提升胃动力并改善消化功能而促使IBS患者康复,对改善患者胃电图参数有积极影响,但与常规剂量相比,小剂量阿米替林安全性更高。Objective To observe the clinical efficacy of amitriptyline in the treatment of irritable bowel syndrome(IBS).Methods 110 IBS patients were selected as the study subjects.They were randomly divided into two groups using a random number table method,with 55 patients in each group.The control group were received adjuvant treatment with conventional dose of amitriptyline,while the experimental group were received low-dose amitriptyline as an adjuvant therapy.The treatment efficacy and safety were compared between two groups of patients.Results At different drug doses,the symptom scores of upper abdominal pain,abdominal burning,and decreased appetite in the experimental group were slightly higher than those in the control group,and there was no statistically significant difference(P>0.05),while the levels of gastrin(GAS),motilin(MLT),pepsin I(PG I),and pepsinⅡ(PGⅡ)were slightly lower than those in the control group(P>0.05).The slow wave value after meals in the experimental group was slightly lower than that in the control group,and the frequency and percentage of gastric electrical disturbances were slightly higher than those in the control group(P>0.05).The incidence of drug-related adverse reactions in the experimental group was lower than that in the control group,showing a statistically significant difference(P>0.05).Conclusion Amitriptyline can promote the recovery of related symptoms in IBS patients by enhancing gastric motility and improving digestive function,and has a positive impact on improving the parameters of the patient′s gastric electrogram.However,compared with conventional doses,low-dose amitriptyline has higher safety.

关 键 词：肠易激综合征 阿米替林 胃动力 消化功能 用药安全性 

分 类 号：R57[医药卫生—消化系统]