戈舍瑞林联合宫腔镜电切术治疗子宫内膜癌的效果分析  

Effect analysis of Goserelin combined with hysteroscopic electroresection in the treatment of endometrial carcinoma

作　　者：李丽 赵慧欣 袁晓敏 LI Li;ZHAO Huixin;YUAN Xiaomin(Department of Obstetrics and Gynecology,Nanyang Hospital of Traditional Chinese Medicine,Nanyang 473000,China)

机构地区：[1]南阳市中医院妇产科,南阳473000

出　　处：《华夏医学》2024年第4期132-138,共7页Acta Medicinae Sinica

基　　金：河南省医学科技攻关联合共建项目(LHGJ20193712)。

摘　　要：目的分析戈舍瑞林联合宫腔镜电切术治疗早期子宫内膜癌的效果。方法选取83例早期子宫内膜癌患者,按照随机数字表法分为对照组41例和观察组42例。对照组接受宫腔镜电切术治疗,观察组接受戈舍瑞林联合宫腔镜电切术治疗,比较两组治疗效果。结果观察组疾病缓解率高于对照组,差异有统计学意义(P<0.05);治疗后,两组肿瘤相关因子水平均降低,且观察组血清糖类抗原125(CA125)、人附睾分泌蛋白4(HE4)、胎盘生长因子(PLGF)水平均低于对照组(P<0.05);治疗后,两组血清促卵泡生成素(FSH)、雌二醇(E2)、黄体生成素(LH)水平均有所变化,且观察组优于对照组(P<0.05);治疗后随访1年,观察组成功受孕率、足月生产率均较对照组高(P<0.05),而两组早产、流产率比较,差异无统计学意义(P>0.05);治疗后,观察组QLQ-C30评分低于对照组(P<0.05)。结论戈舍瑞林联合宫腔镜电切术治疗早期子宫内膜癌,可提高临床疗效,降低肿瘤因子水平,保护卵巢功能,提高妊娠成功率。Objective To analyze the therapentic effect of Goserelin combined with hysteroscopic electroresection in the treatment of patients with early endometrial cancer.Methods 83 patients with early endometrial cancer were selected and grouped by random number table method.The patients in control group(41 cases)were received hysteroscopic electroresection,and the patients in observation group(42 cases)were received Goserelin combined with hysteroscopic electroresection.The therapeutic effect between the two groups was compared.Results The remission rate of disease in observation group was significantly higher than that in control group(P<0.05).After treatment,the levels of tumor related factors were significantly decreased in both groups,and the levels of serum carbohydrate antigen 125(CA125),human epididymal secretory protein 4(HE4)and placental growth factor(PLGF)in observation group were significantly lower than those in control group(P<0.05).After treatment,the serum levels of follicle-stimulating hormone(FSH),estradiol(E2)and luteinizing hormone(LH)in two groups were significantly changed compared with pre-treatment,and the observation group was better than the control group(P<0.05).The successful pregnancy rate and full-term productivity in the observation group were significantly higher than those in the control group(P<0.05),but there was no significant difference in the rates of premature birth and abortion between the two groups(P>0.05).After treatment,the QLQ-C30 score in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Goserelin combined with hysteroscopic resection improves the clinical efficacy of early endometrial cancer,reduces the level of tumor factors,protects ovarian function and improves the success rate of pregnancy.

关 键 词：戈舍瑞林 宫腔镜电切术 早期子宫内膜癌 肿瘤相关因子 卵巢功能 

分 类 号：R737.33[医药卫生—肿瘤]