复方苁蓉益智胶囊联合重复经颅磁刺激治疗VCIND患者的临床效果  

Clinical effects of compound Congrong Yizhi capsule combined with repetitive transcranial magnetic stimulation in the treatment of patients with VCIND

作　　者：蔡航航 王华[1] 柴婉滢 CAI Hanghang;WANG Hua;CHAI Wanying(Department of Neurology,the First Affiliated Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学第一附属医院神经内科,开封475000

出　　处：《华夏医学》2024年第4期151-155,共5页Acta Medicinae Sinica

基　　金：河南省医学科技攻关计划项目(LHGJ20220650)。

摘　　要：目的探讨复方苁蓉益智胶囊联合重复经颅磁刺激(rTMS)治疗非痴呆型血管性认知障碍(VCIND)的临床效果。方法选择92例VCIND患者作为研究对象,按照随机数字表法分为对照组和观察组,每组46例。对照组采用常规药物联合rTMS治疗,观察组采用复方苁蓉益智胶囊联合常规药物及rTMS治疗。比较两组治疗4周后的效果;观察治疗前及治疗4周后两组的认知功能、日常生活活动能力变化;分析治疗期间两组的不良反应发生率差异。结果治疗4周后,观察组的治疗效果优于对照组,差异有统计学意义(P<0.05);观察组的智能精神状态评估量表(MMSE)、认知评定量表(MoCA)、Barthel指数评估量表(BI)评分均高于对照组(P<0.05);两组的不良反应发生率无显著差异(P>0.05)。结论复方苁蓉益智胶囊联合rTMS可有效改善VCIND患者认知功能障碍,提高日常生活活动能力,且安全性良好。Objective To explore the clinical effect of compound Congrong Yizhi capsule combined with repetitive transcranial magnetic stimulation(rTMS)in the treatment of patients with vascular cognitive impairment of non-dementia(VCIND).Methods 92 patients with VCIND were selected as the study subjects and divided into a control group and an observation group according to the random number table method,with 46 cases in each group.The control group were received conventional drug combined with rTMS treatment,while the observation group were received compound Congrong Yizhi capsule combined with conventional drug and rTMS.The treatment effects of the two groups were compared after 4 weeks of treatment.Changes in cognitive function and activities of daily living were observed before and after 4 weeks of treatment in both groups.The differences in the incidence of adverse reactions between the two groups during treatment were analyzed.Results After 4 weeks of treatment,the treatment effect of the observation group was superior to that of the control group,showing a statistically significart difference(P<0.05).The scores of Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),and Barthel Index(BI)in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compound Congrong Yizhi capsule combined with rTMS can effectively improve cognitive dysfunction in patients with VCIND,enhance activities of daily living,and have good safety.

关 键 词：复方苁蓉益智胶囊 重复经颅磁刺激 非痴呆型血管性认知障碍 认知功能 日常生活活动能力 

分 类 号：R743.3[医药卫生—神经病学与精神病学]