2000~2020年27省市精神分裂症时点患病率系统回顾与荟萃分析  

Systematic review and meta-analysis of point prevalence of schizophrenia from 2000 to 2020 in 27 provinces and cities

作　　者：王家威 陶何健 陈海涵 金卫东 孙峰俐[4] 祝希泉 Wang Jiawei;Tao Hejian;Chen Haihan;Jin Weidong;Sun Fengli;Zhu Xiquan(No.988 Hospital of the PLA,Jiaozuo 454003,Henan,China)

机构地区：[1]解放军988医院,河南·焦作454003 [2]浙江中医药大学,浙江杭州310058 [3]浙江省精神卫生中心,浙江杭州311122 [4]浙江省立同德医院,浙江杭州310012

出　　处：《临床心身疾病杂志》2024年第5期101-106,共6页Journal of Clinical Psychosomatic Diseases

基　　金：河南省科技攻关计划联合共建项目(编号LHGJ20220906);全军临床重点专科建设支持项目(编号145AHQ146009000X)。

摘　　要：目的回顾并系统评价近20 a中国精神分裂症时点患病率状况与发展变化趋势。方法利用中、英文数据库(中国生物医学数据库、中国国家知识基础设施数据库、万方数据知识服务平台、维普中文期刊服务平台、Pubmed、Embase、Web of Science)对2000~2020年中国精神分裂症患病情况进行文献检索。收集相关研究的样本量、性别、年龄、样本所在地等资料,根据乔安娜·布里格斯研究所的横断面研究标准,采用Revman 5.2分析精神分裂症患病率及其亚组患病率,运用Begg's检验和Egger's检验进行发表偏倚评估,并通过消除其中任何一篇文章的影响进行敏感性分析。结果最终纳入27篇文章,总样本量为76273839人涉及27个省市,精神分裂症的时点患病率为3.72‰(95%CI:3.30‰~4.22‰)。亚组分析显示,不同性别、年代、年龄段及农村与城市精神分裂症患病率存在统计学差异(P<0.05或0.01)。结论27个省市精神分裂症的患病率与国际大多数研究基本相同。要重视对精神分裂症的早期诊断、治疗、康复和个体化管理。Objective To review and systematically evaluate the point prevalence and development trend of schizophrenia in China in the recent 20 years.Methods Literature on the prevalence of schizophrenia in China from 2000 to 2020 was retrieved using Chinese and English database(CBM,CNKI,WANFANGDATA,CQVIP,Pubmed,Embase,and WOS).Such data of related studies were collected as sample size,gender,age,and sample location.The schizophrenia and its subgroup prevalence were analyzed using Revman 5.2 according to the Joanna Briggs Institute's cross-sectional study criteria,publication bias assessed using Begg's and Egger's test,and sensitivity analyses conducted via eliminating the impact of any one of the literature.Results Finally,twenty-seven articles were included and total sample size was 76,273,839 people,involving 27 provinces and cities.The point prevalence of schizophrenia in China was 3.72‰(95%CI:3.30‰~4.22‰).Subgroup analysis showed that there were statistical differences in the prevalence of schizophrenia in different genders,eras,age groups,rural and urban areas(P<0.05 or 0.01).Conclusion The prevalence of schizophrenia in 27provinces and cities of China is basically the same as that in most international studies.Attention should be paid to the early diagnosis,treatment,rehabilitation and individual management of schizophrenia.

关 键 词：精神分裂症 发病率 流行病学 系统评价 META分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]