血清TK1联合CEA、CA125、CA19-9检查在消化道肿瘤风险筛查中的应用研究  

Study on Application of Serum TK1 Combined with CEA,CA125 and CA19-9 in Screening the Risk of Gastrointestinal Tumor

作　　者：吴珊珊 颜见钦 刘周发 WU Shanshan;YAN Jianqin;LIU Zhoufa(Health Examination Department,Pingxiang People's Hospital,Pingxiang 337000,China)

机构地区：[1]萍乡市人民医院健康体检科,江西萍乡337000

出　　处：《中国医学创新》2024年第24期125-129,共5页Medical Innovation of China

摘　　要：目的:研究血清胸苷激酶1(TK1)联合癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)检查在消化道肿瘤风险筛查中的应用。方法:回顾性分析2020年1月—2023年1月在萍乡市人民医院进行消化道肿瘤风险筛查的80例体检者病历资料,将检出恶性肿瘤的患者纳入恶性肿瘤组(n=30),检出良性肿瘤的患者30例作为良性肿瘤组,20例健康人群作为健康组。检测三组受检者血清TK1、CEA、CA125、CA19-9的水平,比较三组之间肿瘤标志物水平的差异性,并以受试者操作特征(ROC)曲线评估上述指标单一和联合预测恶性肿瘤的诊断价值。结果:恶性肿瘤组和良性肿瘤组患者的TK1、CEA、CA125、CA19-9的水平均高于健康组(P<0.05),且恶性肿瘤组患者肿瘤标志物水平均高于良性肿瘤组,差异均有统计学意义(P<0.05)。TK1预测患有恶性肿瘤的ROC曲线下面积(AUC)为0.894,敏感度和特异度分别为76.47%、96.43%(P<0.05);CEA预测患者患有恶性肿瘤的AUC为0.859,敏感度和特异度分别为88.24%、64.29%(P<0.05);CA125预测患者患有恶性肿瘤的AUC为0.845,敏感度和特异度分别为68.63%、82.14%(P<0.05);CA19-9预测患者患有恶性肿瘤的AUC为0.845,敏感度和特异度分别为98.04%、57.14%(P<0.05);联合检测具有较高敏感度,为100%。结论:较于健康人群,良性肿瘤和恶性肿瘤患者TK1、CEA、CA125、CA19-9水平均升高,恶性肿瘤患者水平显著升高,单一肿瘤标志物的检测效能较低,易出现假阳性而误诊,而联合检测诊断效能较高。Objective:To investigate the application of serum thymidine kinase 1(TK1)combined with carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 19-9(CA19-9)in screening the risk of gastrointestinal tumor.Method:The data of 80 physical examiners who underwent gastroin testinal tumor risk screening in Pingxiang People's Hospital from January 2020 to January 2023 were analyzed retrospectively.Those detected with malignant tumors were included in the malignant tumor group(n=30),those detected with benign tumors were included in the benign tumor group(n=30),and healthy individuals were included in the healthy group(n=20).Serum TK1,CEA,CA125 and CA19-9 levels in the three groups were detected,the differences in tumor markers level among the three groups were compared,the diagnostic value of single marker and combination of above-mentioned markers in predicting malignant tumors was analyzed using the receiver operating characteristic(ROC)curve.Result:The levels of TK1,CEA,CA125 and CA19-9 in the malignant tumor group and the benign tumor group were higher than those in the healthy group(P<0.05),and tumor markers in the malignant tumor group were higher than those in the benign tumor group,the differences were statistically significant(P<0.05).The area under the curve(AUC)of TK1 for predicting malignant tumors was 0.894,sensitivity and specificity were 76.47%and 96.43%,respectively(P<0.05);the AUC of CEA for predicting malignant tumors was 0.859,sensitivity and specificity were 88.24%and 64.29%,respectively(P<0.05);the AUC of CA125 for predicting malignant tumors was 0.845,sensitivity and specificity were 68.63%and 82.14%,respectively(P<0.05);the AUC of CA19-9 for predicting malignant tumors was 0.845,sensitivity and specificity were 98.04%and 57.14%,respectively(P<0.05);the sensitivity of joint prediction was relatively high,which was 100%.Conclusion:Compared with healthy people,patients with benign and malignant tumors have elevated levels of TK1,CEA,CA125 and CA19-9,especially patients wit

关 键 词：消化道肿瘤 体检 血清胸苷激酶1 癌胚抗原 糖类抗原125 糖类抗原19-9 筛查 

分 类 号：R735[医药卫生—肿瘤]