Epigenetic regulation of macrophage polarization in wound healing  

作　　者：Cheng Chen Tengfei Liu Yuanyang Tang Gaoxing Luo Guangping Liang Weifeng He 

机构地区：[1]State Key Laboratory of Trauma,Burn and Combined Injury,Institute of Burn Research,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China [2]Chongqing Key Laboratory for Disease Proteomics,Chongqing 400038,China [3]No.906 Hospital of Joint Logistic Support Force of PLA,Ningbo,Zhejiang,China [4]Academy of Biological Engineering,Chongqing University,Chongqing,China

出　　处：《Burns & Trauma》2023年第1期105-121,共17页烧伤与创伤（英文）

基　　金：supported by grants from the National Natural Sciences Foundation of China(No.81901961 to TFL,No.81630055 andNo.81920108022 to GXL,No.31872742 to WFH);the Military Medical Science and Technology Youth Training Program of the Army Military Medical University(Third Military Medical University)(No.20QNPY024 to WFH);the Special Project for Enhancing Science and Technology Innovation Ability(frontier exploration)of the Army Military Medical University(Third Military Medical University)(No.2019XQY12 to WFH).

摘　　要：The immune microenvironment plays a critical role in regulating skin wound healing.Macrophages,the main component of infiltrating inflammatory cells,play a pivotal role in shaping the immune microenvironment in the process of skin wound healing.Macrophages comprise the classic proinflammatory M1 subtype and anti-inflammatory M2 population.In the early inflammatory phase of skin wound closure,M1-like macrophages initiate and amplify the local inflammatory response to disinfect the injured tissue.In the late tissue-repairing phase,M2 macrophages are predominant in wound tissue and limit local inflammation to promote tissue repair.The biological function of macrophages is tightly linked with epigenomic organization.Transcription factors are essential for macrophage polarization.Epigenetic modification of transcription factors determines the heterogeneity of macrophages.In contrast,transcription factors also regulate the expression of epigenetic enzymes.Both transcription factors and epigenetic enzymes form a complex network that regulates the plasticity of macrophages.Here,we describe the latest knowledge concerning the potential epigenetic mechanisms that precisely regulate the biological function of macrophages and their effects on skin wound healing.

关 键 词：EPIGENETICS Macrophage polarization Wound healing Immune microenvironment Signaling pathways 

分 类 号：R392.2[医药卫生—免疫学]