Polymeric biomaterials-based tissue engineering for wound healing: a systemic review  

作　　者：Pratik Das Suvendu Manna Shivam Roy Samit K.Nandi Piyali Basak 

机构地区：[1]School of Bioscience and Engineering,Jadavpur University,188,Raja Subodh Chandra Mallick Rd,Jadavpur,Kolkata 700032,West Bengal,India [2]Sustainability Cluster,University of Petroleum and Energy Studies,Dehradun 248007,Uttarakhand,India [3]Department of Veterinary Surgery and Radiology,West Bengal University of Animal and Fishery Sciences,Belgachia,Kolkata 700037,West Bengal,India

出　　处：《Burns & Trauma》2023年第1期122-145,共24页烧伤与创伤（英文）

摘　　要：Background:Biomaterials are vital products used in clinical sectors as alternatives to several biological macromolecules for tissue engineering techniques owing to their numerous beneficial properties,including wound healing.The healing pattern generally depends upon the type of wounds,and restoration of the skin on damaged areas is greatly dependent on the depth and severity of the injury.The rate of wound healing relies on the type of biomaterials being incorporated for the fabrication of skin substitutes and their stability in in vivo conditions.In this review,a systematic literature search was performed on several databases to identify the most frequently used biomaterials for the development of successful wound healing agents against skin damage,along with their mechanisms of action.Method:The relevant research articles of the last 5 years were identified,analysed and reviewed in this paper.The meta-analysis was carried out using PRISMA and the search was conducted in major scientific databases.The research of the most recent 5 years,from 2017-2021 was taken into consideration.The collected research papers were inspected thoroughly for further analysis.Recent advances in the utilization of natural and synthetic biomaterials(alone/in combination)to speed up the regeneration rate of injured cells in skin wounds were summarised.Finally,23 papers were critically reviewed and discussed.Results:In total,2022 scholarly articles were retrieved from databases utilizing the aforementioned input methods.After eliminating duplicates and articles published before 2017,∼520 articles remained that were relevant to the topic at hand(biomaterials for wound healing)and could be evaluated for quality.Following different procedures,23 publications were selected as best fitting for data extraction.Preferred Reporting Items for Systematic Reviews and Meta-Analyses for this review illustrates the selection criteria,such as exclusion and inclusion parameters.The 23 recent publications pointed to the use of both natural and synthe

关 键 词：Wound healing BIOMATERIALS Tissue engineering Skin regeneration POLYMERS 

分 类 号：R318[医药卫生—生物医学工程]