A single-stage bilayered skin reconstruction using Glyaderm■as an acellular dermal regeneration template results in improved scar quality:an intra-individual randomized controlled trial  

作　　者：Ignace De Decker Henk Hoeksema Jozef Verbelen Petra De Coninck Marijn Speeckaert Sofie De Schepper Phillip Blondeel Ali Pirayesh Stan Monstrey Karel E.Y.Claes 

机构地区：[1]Burn Center,Ghent University Hospital,C.Heymanslaan 10,9000 Ghent,Belgium [2]Department of Plastic Surgery,Ghent University Hospital,C.Heymanslaan 10,9000 Ghent,Belgium [3]Department of Nephrology,Ghent University Hospital,C.Heymanslaan 10,9000 Ghent,Belgium [4]Department of Dermatology,Ghent University Hospital,C.Heymanslaan 10,9000 Ghent,Belgium [5]Plastic surgeon in private practice in Amsterdam,Amsterdam,The Netherlands

出　　处：《Burns & Trauma》2023年第1期408-428,共21页烧伤与创伤（英文）

基　　金：The Ethical Review Committee of Ghent University Hos-pital approved this prospective study(Belgian registration number B670201733327);The trial was registered on cli nicaltrials.gov and received the following registration code:NCT01033604.

摘　　要：Background:Absence of almost the entire reticular dermal layer is inherent to the use of autologous split-thickness skin grafting(STSG)to close full-thickness wounds,often resulting in hypertrophic scars and contractures.Many dermal substitutes have been developed,but unfortunately most have varying results in terms of cosmetic and/or functional improvement as well as patient satisfac-tion,in addition to high costs.Bilayered skin reconstruction using the human-derived glycerolized acellular dermis(Glyaderm■)has been reported to result in significantly improved scar quality using a two-step procedure.Unlike the necessary two-step procedure for most commercially available dermal substitutes,in this study we aimed to investigate the use of Glyaderm■in a more cost-effective single-stage engrafting.This is a method which,if autografts are available,is preferred by the majority of surgeons given the reduction in costs,hospitalization time and infection rate.Methods:A prospective,randomized,controlled,intra-individual,single-blinded study was per-formed,investigating the simultaneous application of Glyaderm■and STSG vs.STSG alone in full-thickness burns or comparable deep skin defects.During the acute phase,bacterial load,graft take and time to wound closure were assessed and were the primary outcomes.Aesthetic and functional results(secondary outcomes)were evaluated at 3,6,9 and 12 months follow-up using subjective and objective scar measurement tools.Biopsies for histological analysis were taken at 3 and 12 months.Results:A total of 66 patients representing 82 wound comparisons were included.Graft take(>95%),pain management and healing time were comparable in both groups.At 1 year follow-up,the overall Patient and Observer Scar Assessment Scale assessed by the patient was significantly in favour of sites where Glyaderm■was used.Not infrequently,patients attributed this difference to improved skin sensation.Histological analysis showed the presence of a well-formed neodermis,with donor elastin present for up to

关 键 词：Burn SCAR Skin Glyaderm■ Dermal substitute Dermal regeneration template ELASTIN 

分 类 号：R622[医药卫生—整形外科]