肝硬化患者治疗效果的影响因素分析  

Analysis of Influencing Factors on Treatment Efficacy in Patients with Liver Cirrhosis

作　　者：唐莉 潘雪梅[1] 赖雪梅[1] 刘慧[1] TANG Li;PAN Xue-mei;LAI Xue-mei;LIU Hui(Department of Gastroenterology,Third Affiliated Hospital of Sun Yat sen University,Guangzhou,510000)

机构地区：[1]中山大学附属第三医院消化内科,510000

出　　处：《岭南急诊医学杂志》2024年第4期358-361,共4页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨肝硬化患者治疗效果的影响因素。方法:选取2023年4月-2024年4月入院的肝硬化患者为研究对象,采用logistics回归分析肝硬化患者预后的独立影响因素,再采用结构方程模型绘制各因素之间作用的路径图。结果:共纳入研究对象190例,与治疗前相比,治疗后AST值、ALT值均显著下降(P<0.05)。男性、低龄、超重、病程长、低学历、吸烟、饮酒、抑郁、焦虑等是治疗后ALT>40 U/L和AST>40 U/L的危险因素。结构方程模型发现,人口特征、行为疾病、心理因素均对治疗效果(AST或ALT降低)产生影响,以人口特征影响最大。结论:肝硬化患者治疗效果受多种因素的影响,临床上应采用个性化的治疗和护理方法。Objective:To Explore the influencing factors of treatment efficacy in patients with liver cirrhosis.Methods:Liver cirrhosis patients admitted from April 2023 to April 2024 as the research subjects were collected.Logis-tic regression was used to analyze the independent prognostic factors of liver cirrhosis patients.A structural equation mod-eling was constructed and a path diagram of the interactions between various factors was drown.Results:A total of 190 study subjects were included,and compared with before treatment,the level of AST and ALT significantly decreased af-ter treatment(P<0.05).Male,young age,overweight,long disease course,low education,smoking,drinking,depres-sion,and anxiety were risk factors for ALT>40 U/L and AST>40 U/L after treatment.The structural equation model found that demographic characteristics,behavioral disorders,and psychological factors all have an impact on treatment outcomes(reduced AST or ALT),with demographic characteristics having the greatest impact.Conclusion:The treat-ment effect of liver cirrhosis patients was influenced by various factors,and personalized treatment and nursing methods should be adopted in clinical practice.

关 键 词：肝硬化 治疗效果 危险因素 结构方程模型 

分 类 号：R575.2[医药卫生—消化系统]