Atligator Web:A Graphical User Interface for Analysis and Design of Protein-Peptide Interactions  

作　　者：Josef Paul Kynast Birte Höcker 

机构地区：[1]Department of Biochemistry,University of Bayreuth,Bayreuth,Germany.

出　　处：《BioDesign Research》2023年第1期80-85,共6页生物设计研究（英文）

基　　金：the European Research Council H2020-FETopenRIA grant 764434“PRe-ART”and the EIC Transition grant 10105802“PRe-ART-2T”.

摘　　要：A key functionality of proteins is based on their ability to form interactions with other proteins or peptides.These interactions are neither easily described nor fully understood,which is why the design of specific protein–protein interaction interfaces remains a challenge for protein engineering.We recently developed the software ATLIGATOR to extract common interaction patterns between different types of amino acids and store them in a database.The tool enables the user to better understand frequent interaction patterns and find groups of interactions.Furthermore,frequent motifs can be directly transferred from the database to a user-defined scaffold as a starting point for the engineering of new binding capabilities.Since three-dimensional visualization is a crucial part of ATLIGATOR,we created ATLIGATOR web—a web server offering an intuitive graphical user interface(GUI)available at https://atligator.uni-bayreuth.de.This new interface empowers users to apply ATLIGATOR by providing easy access with having all parts directly connected.Moreover,we extended the web by a design functionality so that,overall,ATLIGATOR web facilitates the use of ATLIGATOR with a more intuitive UI and advanced design options.

关 键 词：WEB SERVER intuitive 

分 类 号：Q51[生物学—生物化学]