supported by the National Natural Science Foundation of China(21925701,22321005 and 92153109);the National Key Research and Development Projects(2022YFA1304700);the PKU-AI4S program to C.W;supported by the National Natural Science Foundation of China(22277007);the National Key Research and Development Projects(2022YFA1300008,and 2023YFA1506500)to Y.L.
Metal-binding proteins(MBPs)constitute approximately one-third of the total protein repertoire and play crucial roles in diverse biological processes.The ensemble of MBPs in a specific living system is denoted as‘met...
In every culture,some things are polite,and some are not.Taboos are very bad.People should not do them.If they do,others might get very upset.In the U.S.not tipping a server is taboo.Asking someone,"How old are you?"o...
the National Natural Science Foundation of China(32070572);the Foundation of Key Laboratory of Veterinary Biotechnology(shklab202005);Shanghai,China,and the Science and Technology Commission of Shanghai Municipality(19JC1413000);R.B.G.and J.S.were supported by grants from the Australian Research Council(ARC)(LP220200614).
Proteins secreted by Gram-negative bacteria are tightly linked to the virulence and adaptability of these microbes to environmental changes.Accurate identification of such secreted proteins can facilitate the investig...
funded by Instituto de Salud Carlos Ill(IsCll)and co-funded by the European Union(grants Pl16/00612 and PI20/01200 to MCS);Junta de Andalucia-Consejeria de Salud y Consumo(grant PIER-0468-2019 to MCS);MCS has been supported by ISCIII(JR15/00042);Junta de Andalucia-Consejeria de Salud y Consumo(B-0005-2017);JD has been supported by grants PID2020-117979RB-100 from the Spanish Ministry of Science and Innovation and IMP/00019 from the Instituto de Salud Carlos III(ISCIII);RC has been supported by Junta de Andalucia-Consejeria de Salud y Familias(RH-0052-2021);by the European Union,European Social Fund(FSE)2014-2020.
In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel sequencing.To identify new disease variants,especially in monogenic disorders...
Ministry of Higher Education of Malaysia under theResearch GrantLRGS/1/2019/UKM-UKM/5/2 and Princess Nourah bint Abdulrahman University for financing this researcher through Supporting Project Number(PNURSP2024R235),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
Due to the overwhelming characteristics of the Internet of Things(IoT)and its adoption in approximately every aspect of our lives,the concept of individual devices’privacy has gained prominent attention from both cus...
High power dissipating artificial intelligence (AI) chips require significant cooling to operate at maximum performance. Current trends regarding the integration of AI, as well as the power/cooling demands of high-per...
the National Natural Science Fund Original Exploratory Program(82350110);the National Key R&D Program of China(2019YFA0111000);Program of Shanghai Academic/Technology Research Leader,Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University,the Central Guidance on Local Science and Technology Development Fund(YDZX20233100001002);Shanghai Local College Capacity Building Project(22010502700);J.C.was granted by Youth Foundation of the National Natural Science Foundation of China(82102863),Original Exploration Project of Shanghai Natural Science Foundation(21ZR1480200);Shanghai Rising-Star Program(23QA1400900);Shanghai Youth Medical Talents-Specialist Program(SHWSRS(2023)_062);"Zhuo-Xue Plan"of Fudan University.
Dear Editor,Tonic signaling of chimeric antigen receptors(CARs)plays a pivotal role in governing CAR-T cell fitness:inefficient tonic signaling results in poor CAR-T persistence,while excessive tonic signaling leads t...